Action of pancreatic phospholipase A2 on phosphatidylcholine bilayers in different physical states.

Biochimica Et Biophysica Acta
J A Op den KampL L van Deenen

Abstract

1. Saturated and unsaturated phosphatidylcholines, dispersed as liposomes in water, can be hydrolysed by phospholipase A2 from pig pancreas. A pure saturated phosphatidylcholine is hydrolysed only near its transition temperature. An unsaturated phosphatidylcholine is hydrolysed preferentially near its transition temperature, but hydrolysis can occur also above the transition temperature, albeit at a much lower rate. 2. An equimolar mixture of dimyristoyl phosphatidylcholine and dipalmitoyl phosphatidylcholine, which shows cocrystallization of the paraffin chains, is hydrolyzed between 25 and 40 degrees C with a maximum at 32 degrees C, in agreement with the calorimetric scan of the phase transition. 3. An equimolar mixture of dilauroyl phosphatidylcholine and distearoyl phosphatidylcholine, which shows a monotectic behaviour, is hydrolysed at all temperatures. Hydrolysis is maximal at 0 and 40 degrees C, at which temperatures dilauroyl phosphatidylcholine and distearoyl phosphatidylcholine undergo their phase transition, respectively. 4. Both in the mixture showing cocrystallization and in the mixture in which phase separation occurs, the phosphatidylcholine species with the shorter fatty acid chains is hydrolysed at a higher r...Continue Reading

References

Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·C D LindenC F Fox
Apr 29, 1974·Biochimica Et Biophysica Acta·J A Op den KampL L van Deenen
Oct 23, 1972·Biochimica Et Biophysica Acta·C W HaestL L van Deenen
Apr 16, 1973·Biochimica Et Biophysica Acta·S Batzri, E D Korn
Mar 17, 1972·Biochimica Et Biophysica Acta·C W HaestL L van Deenen

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