Nov 1, 1975

Action of six commonly used benzodiazepines on isolated guinea-pig ileum preparation

Archives Internationales De Pharmacodynamie Et De Thérapie
S HuckC Stumpf


The spasmolytic activity of six commonly used benzodiazepines was investigated on isolated guinea-pig ileum preparation. All six substances proved to be non-competitive antagonists of carbachol and barium chloride, the pD'2 values ranging between 3.23 and 4.37 in the presence of either agonist. The significance of these findings is discussed.

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Anti-Anxiety Effect
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