PMID: 9177894Mar 1, 1997Paper

Action of trypsin:chymotrypsin (Chymoral forte DS) preparation on acute-phase proteins following burn injury in humans

Burns : Journal of the International Society for Burn Injuries
B LathaM Babu

Abstract

A study was carried out to investigate the efficacy of trypsin: chymotrypsin (Chymoral forte DS) preparation on burn patients by analysing the changes taking place in serum acute-phase proteins. Serum proteins were analysed qualitatively and quantitatively for both control and enzyme-treated groups by the methods of Western Blot, ELISA and Turbidimetric assays. Furthermore, the trypsin inhibitory capacity (TIC) of the sera was also determined. Significant differences were observed between a control group of patients and a parallel group treated with trypsin: chymotrypsin preparation. During the first phase of burn wounds an initial rise was seen in C-reactive protein, alpha 1-antitrypsin, alpha 2-macroglobulin and TIC in both the groups. In the following days, enzyme preparation inhibited the rise in C-reactive protein titres and enhanced the rise in alpha 1-antitrypsin, alpha 2-macroglobulin and TIC. The above studies clearly indicate that the changes in serum acute-phase proteins between the control and treated groups reflect the anti-inflammatory activity and hence the therapeutic efficacy of Chymoral forte DS.

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Citations

May 6, 1998·Burns : Journal of the International Society for Burn Injuries·B LathaM Babu
Oct 17, 1998·Burns : Journal of the International Society for Burn Injuries·B LathaM Babu
Apr 2, 2004·International Journal of Clinical Practice·Z OzbalkanS Aksaray
Dec 7, 2017·Advances in Therapy·Dilip Shah, Kushal Mital
Jan 11, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·J LeipnerR Saller
Apr 27, 2021·Expert Opinion on Biological Therapy·Aitor González-TitosMacarena Perán

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