Action on ileal smooth muscle of synthetic detergents and pardaxin

General Pharmacology
N Primor

Abstract

Pardaxin (PX), a toxic and repellent substance isolated from the Red Sea flatfish, causes a sharp ball-like profile of drop of saline placed on a hydrophobic film to turn into a flattened one. This effect results with a decrease of the contact angle (theta) from 96 degrees to a maximum of 42 degrees at 10(-4) M of PX. The action of sodium dodecyl sulphate (SDS), a synthetic anionic detergent, benzalkonium chloride (BAC) cationic detergent and pardaxin (PX) a toxic protein with detergent properties, were studied in the ileal guinea-pig longitudinal smooth muscle preparation. SDS (4 X 10(-4) M) and PX (5 X 10(-6) M) diminished the muscle contractile response to field stimulation (0.1 Hz, 1 msec) and to acetylcholine (Ach) and to histamine and elicited a prolonged (4-6 min) TTX-insensitive muscle contraction. The dose dependence of muscle contraction to SDS and PX was found to be sigmoidal and occurred over a narrow range of concentrations. The SDS- but not PX-induced muscle contraction could be reduced by diphenhydramine (H1 antihistamine). BAC (10(-5)-10(-4) M) suppressed the muscle's contractile response to electrical stimulation (0.1 Hz, 1 msec), to Ach, histamine and 5-hydroxytryptamine but did not produce muscle contraction....Continue Reading

References

Sep 1, 1979·Journal of Medicinal Chemistry·R A FirestoneR J Bonney
Feb 25, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·G BriseidK Kirkevold
Aug 1, 1978·Journal of Steroid Biochemistry·J F StraussG L Flickinger
Nov 30, 1979·The Journal of Membrane Biology·J J Abramson, A E Shamoo
Jan 1, 1978·Drug and Chemical Toxicology·H P Ciuchta, K T Dodd
Jan 1, 1976·Toxicon : Official Journal of the International Society on Toxinology·J Parness, E Zlotkin
Dec 1, 1983·The Journal of Cell Biology·D K MillerR A Firestone
Aug 31, 1982·Biochemical and Biophysical Research Communications·H Birkedal-Hansen, R E Taylor
Dec 1, 1983·Cell Calcium·J V Walsh, J J Singer
Nov 1, 1984·Archives of Toxicology·E Zlotkin, S H Gruber
Nov 1, 1983·Biochimica Et Biophysica Acta·J K ThakkarR C Franson
Oct 1, 1983·Japanese Journal of Pharmacology·H KinemuchiK Kamijo
Jan 1, 1983·Archives of Environmental Contamination and Toxicology·M A Lewis
Sep 7, 1983·Biochimica Et Biophysica Acta·M D WomackR C MacDonald
Apr 1, 1982·Bulletin of Environmental Contamination and Toxicology·A HrabákM T Szabó
Jul 1, 1982·Contact Dermatitis·D P BruynzeelB M von Blomberg-van der Flier
Dec 16, 1980·Biochimica Et Biophysica Acta·N Primor, A T Tu
Dec 1, 1963·Canadian Journal of Biochemistry and Physiology·W D PATON

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