Action potential duration determines sarcoplasmic reticulum Ca2+ reloading in mammalian ventricular myocytes

The Journal of Physiology
Rosana A BassaniD M Bers

Abstract

After sarcoplasmic reticulum (SR) Ca2+ depletion in intact ventricular myocytes, electrical activity promotes SR Ca2+ reloading and recovery of twitch amplitude. In ferret, recovery of twitch and caffeine-induced contracture required fewer twitches than in rabbit or rat. In rat, there was no difference in action potential duration at 90% repolarization (APD90) at steady state (SS) versus at the first post-depletion (PD) twitch. The SS APD90 was similar in ferret and rabbit (but longer than in rat). However, compared to SS, the PD APD90 was lengthened in ferret, but shortened in rabbit. When rabbit myocytes were subjected to AP-clamp patterns during SR Ca2+ reloading (ferret- or rabbit-type APs), reloading was much faster using the ferret AP templates. We conclude that the faster SR Ca2+ refilling in ferret is due to the increased Ca2+ influx during the longer PD AP. The PD versus SS APD90 difference was suppressed by thapsigargin in ferret (indicating Ca2+ dependence). In rabbit, the PD AP shortening depended on the preceding diastolic interval (rather than Ca2+), because rest produced the same AP shortening, and SS APD90 increased as a function of frequency (in contrast to ferret). Transient outward current (Ito) was larger an...Continue Reading

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Citations

Jan 6, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Michelle M Monasky, Paul M L Janssen
Aug 8, 2007·Pflügers Archiv : European journal of physiology·Rafael A RicardoJosé W M Bassani
Feb 19, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eleonora GrandiSilvio Cavalcanti
Oct 12, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Min DongHong-Sheng Wang
Oct 27, 2009·The Journal of Clinical Investigation·Mark D LevinVickas V Patel
Oct 4, 2012·IEEE Transactions on Bio-medical Engineering·Alexandra V S FonsecaJosé W M Bassani
Nov 8, 2008·IEEE Transactions on Bio-medical Engineering·Pedro Xavier de OliveiraJosé Wilson Magalhães Bassani
Jun 30, 2016·Channels·Giedrius Kanaporis, Lothar A Blatter
Jun 11, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Artur Santos-MirandaDanilo Roman-Campos
Jan 24, 2012·The Canadian Journal of Cardiology·Yves T WangYuanna Cheng
Feb 28, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R A Bassani
Mar 5, 2017·Journal of Molecular and Cellular Cardiology·Giedrius Kanaporis, Lothar A Blatter
May 5, 2017·Clinical Medicine Insights. Cardiology·Andrew G Edwards, William E Louch
May 5, 2012·Circulation Research·Elspeth B ElliottChristopher M Loughrey
Dec 24, 2014·Circulation Research·Giedrius Kanaporis, Lothar A Blatter
May 12, 2006·Journal of Cardiovascular Electrophysiology·Eric A SobieW J Lederer
Apr 16, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Noriko SaegusaKenneth W Spitzer
Jul 2, 2017·Medicina·Giedrius Kanaporis, Lothar A Blatter
Dec 21, 2014·American Journal of Physiology. Heart and Circulatory Physiology·B Cicero WillisJulio Altamirano
Jan 2, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Julian LandawZhilin Qu
Feb 9, 2021·Computers in Biology and Medicine·Robson Rodrigues da SilvaRosana Almada Bassani
Oct 19, 2011·European Journal of Pharmacology·Sandra Valeria Santos de CerqueiraCarla Maria Lins de Vasconcelos
Sep 7, 2004·Biophysical Journal·Thomas R ShannonDonald M Bers
Sep 3, 2021·Circulation Research·Antonio Zaza, Francesco Lodola
Oct 1, 2008·Drug Discovery Today. Disease Models·Steven M Pogwizd, Donald M Bers

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