PMID: 6982421Nov 11, 1982Paper

Action potential repolarization may involve a transient, Ca2+-sensitive outward current in a vertebrate neurone

Nature
A B MacDermott, F F Weight

Abstract

Repolarization of the action potential in squid axon1 and several types of neurones2-4 involves a voltage-activated potassium (K+) current. Voltage clamp analysis has demonstrated that this current has rapid activation kinetics1,3-5. In several neuronal types, the same technique has also revealed a slowly activated K+ current that is calcium (Ca2+)-sensitive3,5-10. This slow Ca2+-activated K+ current is the major current underlying the late, slower portion of the after-hyperpolarization following an action potential11-14. In several muscle types, fast, transient Ca2+-dependent K+ currents have been described15-17 which may contribute to repolarization of the action potential. Rapidly activating, Ca2+-dependent K+ currents have been observed in sympathetic neurones of the bullfrog and it has been suggested that they contribute to action potential repolarization of those neurones8,9,18. We have studied the membrane currents in bullfrog sympathetic neurones using voltage clamp methods and report here a transient outward current that appears to be composed of two separate currents. One of those currents is a transient, Ca2+-sensitive outward current as indicated by a significant reduction of the current by treatments that reduce or...Continue Reading

References

Jan 1, 1978·Annual Review of Biophysics and Bioengineering·R W Meech
May 1, 1979·The Journal of Physiology·D A McAfee, P J Yarowsky
Jun 1, 1979·The Journal of Physiology·R W AldrichS H Thompson
Jun 1, 1979·The Journal of Physiology·R W AldrichS H Thompson
Feb 1, 1977·The Journal of Physiology·S H Thompson
Feb 1, 1971·The Journal of Physiology·J A Connor, C F Stevens
Feb 1, 1971·The Journal of Physiology·J A Connor, C F Stevens
Jun 1, 1980·The Journal of General Physiology·D C Eaton, M S Brodwick
Jan 1, 1981·Annual Review of Neuroscience·S Hagiwara, L Byerly
Jul 1, 1981·The Journal of General Physiology·A Hermann, A L Gorman
Jun 1, 1980·Biophysical Journal·C M Armstrong, S R Taylor
Jul 1, 1981·Journal of Neurophysiology·P C Schwindt, W E Crill
Feb 1, 1980·The Journal of Physiology·S A Siegelbaum, R W Tsien
Jan 1, 1980·The Journal of General Physiology·A B MacDermottR L Parsons
Feb 9, 1981·Brain Research·A ConstantiD A Brown
Feb 1, 1982·Pflügers Archiv : European journal of physiology·E Coraboeuf, E Carmeliet
Jul 1, 1980·The Journal of Physiology·E F BarrettW E Crill

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Citations

Jan 1, 1990·Pflügers Archiv : European journal of physiology·R Y Pun, M M Behbehani
Jan 1, 1989·Pflügers Archiv : European journal of physiology·P JirounekE Chardonnens
Nov 1, 1986·Pflügers Archiv : European journal of physiology·M Gho, A Mallart
Jan 1, 1991·Progress in Biophysics and Molecular Biology·O Belluzzi, O Sacchi
Aug 1, 1987·Computer Methods and Programs in Biomedicine·M A LindleyJ M Horowitz
Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·M E KellyP A Smith
Jul 1, 1994·Progress in Neurobiology·P A Smith
Jun 18, 1986·Neuroscience Letters·M E KellyP A Smith
Jun 1, 1988·Neuroscience·B Rudy
Jul 16, 1999·Neurochemistry International·A M DopicoS N Treistman
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M H BassantJ M Billard
Oct 31, 2002·The European Journal of Neuroscience·Mary D Womack, Kamran Khodakhah
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P PennefatherR A Nicoll
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J V HalliwellJ O Dolly
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T ElkinsC F Wu
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A B Ribera, N C Spitzer
Jan 15, 2014·Pflügers Archiv : European journal of physiology·Ray W Turner, Gerald W Zamponi
Jan 16, 2004·The Journal of Physiology·Sarah A LocknarRodney L Parsons

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