Actions and interactions of dihydropyridines and ethanol on the rat sinus node

Cardiovascular Drugs and Therapy
P P SalvaticiR G Carpentier

Abstract

The actions and interactions of dihydropyridines (DHPs) and ethanol on sinus node (SN) automaticity were studied using rat sinoatrial preparations superfused with Tyrode's solution at 37 degrees C. Intracellular microelectrodes were used to monitor SN rate (SNR). The automaticity of the SN was not affected by nimodipine 10(-10) M, but it was depressed by a higher concentration of this calcium antagonist (10(-8) M). The racemic compound (+/-)Bay K 8644 had a dose-dependent biphasic chronotropic action: At 10(-8) M it decreased the SNR, while at 10(-7) M it increased the SNR. The negative component was blocked by atropine. A small concentration of ethanol (1.8 x 10(-2) M) had a positive chronotropic effect on the SN, and this action was blocked by nimodipine 10(-10) M. This small concentration of ethanol did not modify the chronotropic effects of either of the DHPs. A higher concentration of ethanol (5.3 x 10(-2) M) did not by itself affect the SNR, but it antagonized the chronotropic actions of the two DHPs.

References

Apr 21, 1977·European Journal of Pharmacology·R CarpentierS Sanhueza
Aug 15, 1985·European Journal of Pharmacology·G FranckowiakG Thomas
May 1, 1987·Journal of Molecular and Cellular Cardiology·A Schwartz
May 1, 1987·Journal of Molecular and Cellular Cardiology·M Bechem, M Schramm
Dec 1, 1987·Experientia·H Irisawa
Dec 1, 1987·Journal of Cardiovascular Pharmacology·R G Carpentier, A Gallardo-Carpentier
Jan 1, 1985·Alcoholism, Clinical and Experimental Research·A WatanabeA Fujimoto
Mar 17, 1983·The New England Journal of Medicine·G S AllenC R Transou

❮ Previous
Next ❯

Citations

Dec 1, 1992·Cardiovascular Drugs and Therapy·M G Worthington, L H Opie
Mar 1, 1992·Alcohol·O R CarrylR G Carpentier
Jul 1, 1992·Alcohol·R P SalvaticiR G Carpentier
Jul 25, 1997·International Journal of Cardiology·D J StandenR G Carpentier
Nov 10, 1998·Clinical and Experimental Pharmacology & Physiology·C S SchulzR G Carpentier
Mar 1, 1991·Alcohol·O R CarrylR G Carpentier
Apr 1, 1990·Journal of Electrocardiology·R P SalvaticiR G Carpentier
Apr 17, 1998·Immunopharmacology and Immunotoxicology·P P SfikakisP Panayiotidis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.