PMID: 2507088Sep 11, 1989Paper

Actions of arachidonic acid and hepoxilin A3 on mammalian hippocampal CA1 neurons

Brain Research
P L CarlenC R Pace-Asciak

Abstract

The effects of arachidonic acid and its lipoxygenase metabolites, the hepoxilins, were investigated in rat hippocampal CA1 neurons in vitro by intracellular electrophysiological recordings. Both arachidonic acid and the hepoxilins cause a hyperpolarization which is sometimes followed by a later depolarization, augment the postspike train long-lasting afterhyperpolarization (AHP) and increase orthodromic inhibitory postsynaptic potentials (IPSPs). These data show that this arachidonic acid metabolic pathway has significant actions on mammalian central neurons, and may represent an important mechanism of neuromodulation.

References

Feb 1, 1978·The Journal of Physiology·K KrnjevićR Werman
Sep 11, 1989·Brain Research·P L CarlenC R Pace-Asciak
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A L HultingB Samuelsson
Feb 29, 1988·Biochemical and Biophysical Research Communications·C R Pace-Asciak
Jul 1, 1987·Prostaglandins, Leukotrienes, and Medicine·E ShohamiG Feuerstein
Feb 1, 1980·Journal of Neurophysiology·J R Hotson, D A Prince
Nov 1, 1984·Prostaglandins, Leukotrienes, and Medicine·C R Pace-Asciak, J M Martin

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Citations

Oct 1, 1993·Biulleten' eksperimental'noĭ biologii i meditsiny·A S PivovarovG I Miagkova
Sep 1, 1991·Neurochemical Research·L Pellerin, L S Wolfe
Jun 19, 1991·Biochimica Et Biophysica Acta·O LaneuvilleC R Pace-Asciak
Nov 17, 1994·Biochimica Et Biophysica Acta·C R Pace-Asciak
Sep 11, 1989·Brain Research·P L CarlenC R Pace-Asciak
Sep 1, 1990·Trends in Pharmacological Sciences·D Piomelli, P Greengard
Jan 1, 1991·Neurochemistry International·N C SchaadM Schorderet
Jul 1, 1993·General Pharmacology·C R Pace-Asciak
Oct 1, 1995·Journal of Lipid Mediators and Cell Signalling·T Yoshimoto, S Yamamoto
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C R Pace-AsciakP L Carlen
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C D FunkB Samuelsson
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A MargalitA A Livne
Jan 1, 1991·Annals of the New York Academy of Sciences·B E Alger
Feb 1, 1992·Journal of Neurochemistry·S C AmrutheshE F Ellis
Apr 1, 1992·Journal of Neurochemistry·M NishiyamaT Kirino
Jul 5, 2007·The FEBS Journal·Santosh NigamRenate Roux-Van der Merwe
May 25, 2010·Journal of Neurochemistry·Matthew W BuczynskiEdward A Dennis
Dec 31, 1990·Biochemical and Biophysical Research Communications·C R Pace-AsciakE J Corey
Oct 4, 2005·Biochemical and Biophysical Research Communications·Santosh Nigam, Maria-Patapia Zafiriou
Aug 30, 1991·Biochemical and Biophysical Research Communications·Z LinC R Pace-Asciak
Jul 25, 1997·The Journal of Biological Chemistry·D J SteelS J Feinmark
May 9, 2009·British Journal of Pharmacology·Cecil R Pace-Asciak
Jan 1, 1994·Journal of Neurochemistry·D ReynaudC R Pace-Asciak
Sep 23, 2014·Biochimica Et Biophysica Acta·Cecil R Pace-Asciak
Mar 1, 1997·Progress in Lipid Research·S YamamotoN Ueda
Sep 28, 1990·Biochemical and Biophysical Research Communications·S NigamC R Pace-Asciak
Mar 8, 2005·Progress in Lipid Research·John W NewmanBruce D Hammock

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