Actions of centrally administered neuropeptides on rat intestinal transport: enhancement of ileal absorption by angiotensin II

European Journal of Pharmacology
D R Brown, M A Gillespie

Abstract

Recent evidence suggests that opioids and other peptides may act within the CNS to modulate intestinal fluid and ion transport. In this study, the brain peptides bombesin and angiotensin II were examined for their ability to alter water flux across the small intestine after their intracerebroventricular (i.c.v.) administration to rats. In addition, changes in mean arterial pressure and respiratory frequency were determined after peptide treatment to assess the physiological specificity of their CNS actions. Bombesin, administered by i.c.v. bolus injections (10-1000 ng/rat) or continuous infusion (100 ng/min), rapidly elevated blood pressure and respiration, but had no significant effect on water transport in proximal jejunum or distal ileum in situ (as measured by single-pass perfusion with [14C]polyethylene glycol as non-absorbed water marker). Angiotensin II rapidly increased blood pressure and enhanced ileal absorption 30 min after its i.c.v. bolus injection at 0.1-1 microgram, but had no effect on jejunal transport or respiration. These effects were inhibited in rats pretreated with either the angiotensin antagonist [Sar1, Val5, Ala8]angiotensin II (5 micrograms i.c.v.) or the alpha-adrenoceptor antagonist, phentolamine (1 ...Continue Reading

References

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Citations

Jun 1, 1990·Digestive Diseases and Sciences·R FogelG Michelson
May 1, 1989·Brain Research·T UngerP Rohmeiss
Jan 1, 1994·Baillière's Clinical Endocrinology and Metabolism·J J Holst, P Schmidt
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Nov 27, 2008·European Journal of Pharmacology·Katarzyna Kaczyńska, Małgorzata Szereda-Przestaszewska
May 24, 2011·Pharmacological Reports : PR·Katarzyna Kaczyńska, Małgorzata Szereda-Przestaszewska
Aug 12, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Guo-Du WangJackie D Wood

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