PMID: 14417244Dec 1, 1959Paper

Actions of dimethylphenylpiperazinium

British Journal of Pharmacology and Chemotherapy
H W LING

Abstract

The actions of 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) have been studied to discover under what conditions a blocking action could be seen. Dimethylphenylpiperazinium has a stimulant action on autonomic ganglia, stimulating the superior cervical ganglion and causing contraction of the nictitating membrane. It caused slowing followed by acceleration of the rate of beat of isolated rabbit atria. The denervated gastrocnemius muscle contracted if dimethylphenylpiperazinium was injected intra-arterially. Under other circumstances a blocking action was seen. It blocked peristalsis in the isolated guinea-pig ileum stimulated by raising intraluminal pressure and inhibited the response of the rat diaphragm and of the cat gastrocnemius stimulated through the motor nerve. It is suggested that dimethylphenylpiperazinium acts by depolarization, causing stimulation of resting muscle but inhibition by prolonging depolarization.

References

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Citations

Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·J R Fozard, E Muscholl
Nov 1, 1970·The American Journal of Digestive Diseases·J K Kyi, E E Daniel
Feb 1, 1968·Comparative Biochemistry and Physiology·R J Walker, A Hedges
Jul 1, 1970·European Journal of Pharmacology·R Brus, D Jacobowitz
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Mar 1, 1976·European Journal of Pharmacology·H Kuromi, Y Hagihara
Jan 1, 1986·Brain Research Bulletin·D B Beleslin, S K Krstić
Aug 23, 2001·Autonomic Neuroscience : Basic & Clinical·M StorrH D Allescher
Apr 1, 1963·British Journal of Pharmacology and Chemotherapy·J H BURN, H FROEDE
Jun 1, 1963·British Journal of Pharmacology and Chemotherapy·J HARRY
Oct 1, 1963·British Journal of Pharmacology and Chemotherapy·G BROWNLEE, E S JOHNSON
Aug 1, 1964·British Journal of Pharmacology and Chemotherapy·M F CUTHBERT
Aug 1, 1966·British Journal of Pharmacology and Chemotherapy·A Bennett, B Whitney
Aug 1, 1966·British Journal of Pharmacology and Chemotherapy·P I Akubue
Feb 1, 1968·British Journal of Pharmacology and Chemotherapy·W D Paton, E C Savini
Jun 1, 1962·British Journal of Pharmacology and Chemotherapy·B GOMEZ ALONSO DE LA SIERRA
Apr 8, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S M Janković, D B Beleslin
Sep 1, 1968·The Journal of Pharmacy and Pharmacology·M G Tweeddale
Mar 7, 2021·Biophysical Journal·Dinesh C Indurthi, Anthony Auerbach

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