Actions of endothelin-1 on prostaglandin production by gestational tissues

Prostaglandins
M D MitchellS S Edwin

Abstract

Endothelin-1 (10(-11)M-10(-7)M) was incubated with human umbilical vein endothelial cells and cells derived from amnion and decidua and prostaglandin production was determined. The rates of biosynthesis of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) and prostaglandin E2 (PGE2) by endothelial cells were increased significantly by treatment with endothelin-1. Amnion cell PGE2 production was reduced significantly by endothelin-1 treatment whereas decidual PGE2 and prostaglandin F2 alpha production was unaffected by this treatment. Thus, it is possible that endothelins may play a part in the regulation of uteroplacental hemodynamics and the mechanisms of parturition.

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Citations

Oct 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A TatraiP H Stern
Aug 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Tatrai, P H Stern
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Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Nonna MakkonenPertti Kirkinen
Aug 14, 1992·Biochemical and Biophysical Research Communications·T KoshiT Okabe
Dec 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M P Schrey, A Hare
Dec 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·O Ylikorkala, L Viinikka

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