Actions of locally administered adrenoceptor agonists on increased plasma protein extravasation and blood flow in guinea-pig skin

British Journal of Pharmacology
J L Beets, W Paul

Abstract

1 Bradykinin-induced increased plasma protein extravasation (IPPE) and blood flow have been assessed in guinea-pig skin by isotopic methods. 2 alpha-Adrenoceptor agonists inhibited IPPE and reduced cutaneous blood flow. The potency of alpha-agonists as inhibitors of IPPE correlated with their vasoconstrictor effects. The actions of noradrenaline on both IPPE and blood flow were blocked by phentolamine but not by propranolol. 4 beta-Adrenoceptor agonists inhibited IPPE at doses which either increased or caused little change in cutaneous blood flow. Isoprenaline inhibition of IPPE was reduced by propranolol but was unaffected by phentolamine. 5 The inhibitory action of alpha-agonists on IPPE can be explained by a reduction in blood flow to the affected site. Beta agonist inhibition is not due to effects on blood flow but is probably caused by a reduction in permeability of the microvessels.

References

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Citations

Dec 1, 1984·Agents and Actions·F De ClerckR S Reneman
Dec 1, 1981·Agents and Actions·J MorleyW Paul
Feb 24, 1987·European Journal of Pharmacology·B R LindgrenR G Andersson
Jun 1, 1984·Immunopharmacology·N BloksmaJ M Willers
Aug 1, 1983·Prostaglandins, Leukotrienes, and Medicine·J MorleyC Gandolfi
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Mar 6, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Stefan LeisFrank Birklein
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Jan 20, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P StjärneJ A Nadel
Nov 1, 1983·British Journal of Pharmacology·J MorleyW Paul
Jan 1, 1982·Annals of the New York Academy of Sciences·C G PerssonE Svensjö

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