Actions of moguisteine on cough and pulmonary rapidly adapting receptor activity in the guinea pig

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
T MorikawaJ G Widdicombe

Abstract

With anaesthetized guinea pigs, the actions of moguisteine were tested on the cough reflex, the resting discharge of lung rapidly adapting receptors (RARs), RAR activity induced by aerosols of capsaicin, stimulation of RARs due to i.v. injection of capsaicin, and on the reflex responses to i.v. capsaicin. I.v. moguisteine (20 microg kg(-1)), compared with vehicle, decreased the spontaneous firing of RARs. Intragastric (i.g.) moguisteine (200 mg kg(-1)) had no effect on resting discharge. I.g. moguisteine depressed the cough response due to capsaicin aerosol (0.01(-1) mg ml(-1)) and significantly reduced the increased discharge of the RARs due to the aerosol. I.v. and i.g. moguisteine reduced the proportionate increase in RAR discharge due to i.v. capsaicin (50 microg kg(-1)). It did not appreciably affect the cardiovascular and respiratory responses to i.v. capsaicin, which presumably activated lung C-fibre receptors. We conclude that the antitussive action of moguisteine is mediated at least in part by a decrease in the excitatory response of RARs to tussive stimuli.

References

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Citations

Jan 27, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Noriyuki OhkuraNobuyuki Katayama
May 6, 2009·Experimental Lung Research·Noriyuki OhkuraShinji Nakao
Dec 1, 2006·Respiratory Physiology & Neurobiology·Federico LavoriniGiovanni A Fontana
Jun 8, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Noriyuki OhkuraNobuyuki Katayama
Aug 13, 2004·European Journal of Pharmacology·Junzo KameiAkiyoshi Saitoh
Jun 3, 2006·Respiratory Physiology & Neurobiology·Brendan J CanningStuart B Mazzone
Jul 9, 2002·Pulmonary Pharmacology & Therapeutics·Brendan J Canning
Nov 19, 2015·PloS One·Toshiyuki IwataMichiaki Mishima
Jun 24, 2016·Experimental Lung Research·Noriyuki OhkuraMasaki Fujimura
Jun 3, 2011·International Journal of Toxicology·Sheela SharmaVernon E Steele
Oct 3, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yu-long LuoWei-wei Su
Mar 29, 2014·Pharmacological Reviews·P V DicpinigaitisC P Page
Jun 10, 2016·Physiological Reviews·Stuart B Mazzone, Bradley J Undem

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