PMID: 3745778Jul 1, 1986Paper

Actions of morphine and enkephalins on the internal anal sphincter of the cat: relevance for the physiological role of opiates

Journal of the Autonomic Nervous System
M BouvierJ Gonella

Abstract

The effects of Leu-enkephalin, Met-enkephalin and morphine on the electrical activity of the internal anal sphincter were studied in anesthetized spinalized cats and in vitro on sphincteric muscle strips. All the effects of enkephalins and morphine were antagonized by naloxone (2 mg/kg, i.v. in vivo and 10(-6)M in vitro). In vivo, the enkephalins (0.01 mg/kg i.v.) and morphine (2 mg/kg, i.v.) decreased the amplitude of the excitatory responses evoked in the sphincter by stimulation of the hypogastric nerves. Opiates presumably act on the sympathetic nerve endings by reducing the release of noradrenaline. In vitro, the enkephalins (10(-6)M) and morphine (10(-6)M) had a similar inhibitory effect, indicating that opiates act, at least partly, at intramural level. In vivo, the enkephalins and morphine produced an inhibition of the spontaneous electrical activity of the internal anal sphincter. This inhibition occurs also in vitro; it is thus due to a peripheral effect of opiates acting either directly on the sphincteric smooth muscle cells, or through the nervous structures controlling sphincteric motility. In addition, the distribution of nerves containing enkephalin-like immunoreactivity, using whole mount preparations of cat int...Continue Reading

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Citations

Dec 1, 1988·Journal of the Autonomic Nervous System·F MulèS Abbadessa-Urso
Nov 1, 1987·Peptides·G A OlsonA J Kastin
Dec 14, 1996·Journal of the Autonomic Nervous System·S BuntzenS Nordgren
May 12, 1997·Journal of the Autonomic Nervous System·D BagnolY Julé
Jul 1, 1988·Acta Physiologica Scandinavica·A CarlstedtS Nordgren
Sep 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·M Bouvier
Feb 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C PorcherM Henry
Oct 8, 2017·Digestive Diseases and Sciences·Jakob Lykke PoulsenAsbjørn Mohr Drewes
Dec 31, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Stefan Müller-LissnerBart Morlion
Dec 1, 1996·Pediatric Surgery International·B Husberg, M Schultzberg
Apr 20, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S Rattan
Oct 27, 2021·Digestive Diseases and Sciences·Nayna A LodhiaWalter W Chan

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