Nov 1, 1992

Actions of noradrenaline on myenteric neurons in the guinea pig gastric antrum

Journal of the Autonomic Nervous System
Jan Tack, J D Wood

Abstract

We used intracellular electrophysiological recording to study the actions of noradrenaline on myenteric neurons in the guinea pig gastric antrum. Noradrenaline caused a dose-dependent inhibition of the stimulus-evoked cholinergic fast excitatory postsynaptic potentials (EPSPs). Noradrenaline had no effect on the postsynaptic response to acetylcholine, suggesting a presynaptic site of action. The slow EPSP was also presynaptically inhibited by noradrenaline. In only 5% of the neurons, noradrenaline caused a postsynaptic depolarization, accompanied by increased input resistance and enhanced excitability. Studies with adrenergic antagonists and agonists revealed that the presynaptic inhibitory effect was mediated by an alpha 2-receptor, while the postsynaptic excitatory effect seemed to be mediated by an alpha 1 receptor. We conclude that noradrenaline inhibits neurotransmitter release from cholinergic and non-cholinergic nerve terminals in the myenteric plexus of the antrum and that it excites a subpopulation of antral neurons. Both mechanisms may contribute to the neurally mediated inhibitory action of noradrenaline on gastric contractility.

Mentioned in this Paper

Pyloric Antrum
Entire Auerbach's Plexus
Neurotransmitter Secretion
Cavia
Protoplasm
Resting Potentials
Neurons
Acute Cholinergic Dysautonomia
Synaptic Transmission
Antral

About this Paper

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