Abstract
Teratogenic alkaloids are found in many species of plants including Conium maculatum L., Nicotiana glauca, Nicotiana tabaccum, and multiple Lupinus spp. Fetal musculoskeletal defects produced by alkaloids from these plants include arthrogyropisis, scoliosis, torticollis, kyposis, lordosis, and cleft palate. A pharmacodynamic comparison of the alkaloids ammodendrine, anabasine, anabaseine, anagyrine, and coniine in SH-SY5Y cells and TE-671 cells was made. These alkaloids and their enantiomers were more effective in depolarizing TE-671 cells which express the human fetal-muscle type nicotinic acetylcholine receptor (nAChR) relative to SH-SY5Y cells which predominately express autonomic nAChRs. The rank order of potency in TE-671 cells was: anabaseine>(+)-anabasine>(-)-anabasine > (+/-)-anabasine>anagyrine>(-)-coniine > (+/-)-coniine>(+)-coniine>(+/-)-ammodendrine>(+)-ammodendrine. The rank order potency in SH-SY5Y cells was: anabaseine>(+)-anabasine>(-)-coniine>(+)-coniine>(+)-ammodendrine>anagyrine>(-)-anabasine>(+/-)-coniine>(+/-)-anabasine>(-)-ammodendrine. The actions of these alkaloids at nAChRs in both cell lines could be distinguished by their maximum effects in depolarizing cell membrane potential. The teratogenic action ...Continue Reading
References
Jan 1, 1978·Clinical Toxicology·R F Keeler, L D Balls
Jul 1, 1976·Journal of Toxicology and Environmental Health·R F KeelerJ L Shupe
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·K E PanterR J Callan
Jan 1, 1990·Journal of Toxicology. Clinical Toxicology·K E PanterR J Callan
Nov 1, 1989·Teratology·R F Keeler, K E Panter
Jan 1, 1971·Toxicon : Official Journal of the International Society on Toxinology·R M CoatesB C Abbott
Mar 1, 1983·Journal of Toxicology. Clinical Toxicology·R F Keeler, M W Crowe
Oct 23, 1998·Invertebrate Neuroscience : in·W R Kem
Apr 1, 1999·Journal of Pharmacological and Toxicological Methods·A H Lichtman
May 26, 1999·Toxicon : Official Journal of the International Society on Toxinology·T A LópezM L Bianchini
Mar 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Richard W FitchJohn W Daly
Dec 1, 1963·British Journal of Pharmacology and Chemotherapy·R B BARLOWR P STEPHENSON
Feb 6, 2004·British Journal of Pharmacology·H-J BehrendtR Jostock
Jun 1, 2005·Journal of Natural Products·Stephen T LeeMassoud Garrossian
Aug 3, 2005·Cellular and Molecular Neurobiology·John W Daly
Feb 21, 2006·Neurotoxicology and Teratology·Stephen T LeeJames A Pfister
Mar 6, 1981·Science·J W WheelerR M Duffield
Apr 29, 2008·Phytochemical Analysis : PCA·Stephen T LeeRussell J Molyneux
Jul 31, 2008·The Journal of Pharmacology and Experimental Therapeutics·Neal InnocentSusan Wonnacott
Sep 4, 2008·Chemical Research in Toxicology·Stephen T LeeKip E Panter
Nov 18, 2008·Plant Molecular Biology·Kathleen D DeboerJohn D Hamill
Citations
Nov 3, 2011·PloS One·Chiara LauritanoAdrianna Ianora
Dec 23, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Zakiah IsmailIbrahim Jantan
Nov 28, 2012·Phytochemistry·Kathleen D DeBoerJohn D Hamill
Apr 25, 2012·Plant Science : an International Journal of Experimental Plant Biology·S M RyanJ D Hamill
Sep 30, 2015·Toxicon : Official Journal of the International Society on Toxinology·Benedict T GreenDale R Gardner
Sep 6, 2015·Toxicon : Official Journal of the International Society on Toxinology·Benedict T GreenT Zane Davis
May 25, 2013·Journal of Applied Toxicology : JAT·K D WelchK E Panter
Dec 18, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Benedict T GreenKip E Panter
Apr 29, 2015·Research in Veterinary Science·Benedict T GreenT Zane Davis
Mar 28, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Benedict T GreenDavid R Brown
Nov 9, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Niko RadulovićFabio Boylan
Apr 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Benedict T GreenKip E Panter
May 11, 2011·European Journal of Pharmacology·Benedict T GreenDale R Gardner
Jun 7, 2014·Toxicon : Official Journal of the International Society on Toxinology·K D WelchJ A Pfister
Nov 15, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hannu Hotti, Heiko Rischer
Oct 23, 2012·The Journal of Pharmacology and Experimental Therapeutics·Benedict T GreenKip E Panter
Feb 15, 2020·Marine Drugs·Hong XingWilliam R Kem
Nov 2, 2019·Marine Drugs·Kristin AndrudWilliam Kem
Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elisa BonandiDaniele Passarella
Jul 8, 2016·Toxins·Benedict T GreenWilliam R Kem
Apr 29, 2020·Reproductive Toxicology·Xabier CendoyaFrancisco J Planes
May 12, 2017·Research in Veterinary Science·Benedict T GreenDaniel Cook
Feb 17, 2018·Toxicon : Official Journal of the International Society on Toxinology·B T GreenW R Kem
Oct 10, 2020·The Veterinary Clinics of North America. Food Animal Practice·Bryan L StegelmeierMichael J Clayton
Jun 19, 2020·Toxicon: X·Benedict T GreenKevin D Welch
Mar 22, 2013·Chemical Research in Toxicology·Stephen T LeeDale R Gardner
Jul 16, 2013·Chemical Research in Toxicology·Benedict T GreenStephen T Lee