Actions of prostaglandin precursors and other unsaturated fatty acids on conduction time and refractory period in the cat heart in situ

British Journal of Pharmacology
B L Bayer, W Förster

Abstract

1 The effect of arachidonic, dihomo-gamma-linolenic, linoleic, alpha-linolenic and oleic acid, given by intravenous infusion, on conduction time and functional refractory period have been studied in the cat heart in situ. 2 The prostaglandin precursors, arachidonic acid and dihomo-gamma-linolenic acid, prolonged the conduction time and the functional refractory period. Linoleic acid was also effective but to a lesser degree. alpha-Linolenic acid and oleic acid showed no or only a weak effect in thie respect. 3 Pretreatment was indomethacin diminished or abolished the actions of the three effective fatty acids but not those of prostaglandin E2. 4 The results suggest that the effects of prostaglandin prostaglandin precursors on conduction time and refractory period are responsible for their antiarrhythmic effectiveness and that these effects are attributable to their endogenous conversion into prostaglandins.

References

Jan 1, 1977·Nutrition and Metabolism·A G HassamM A Crawford
Feb 1, 1975·Journal of Molecular and Cellular Cardiology·L H Opie, W F Lubbe
Nov 13, 1975·Nature·J P RiversM A Craqford
Jan 1, 1971·European Journal of Clinical Investigation·V A KurienM F Oliver
Apr 27, 1974·Lancet·M F OliverM J Rowe
Aug 1, 1973·The Journal of Pharmacy and Pharmacology·C Larsson, E Anggard
Jan 1, 1971·Annual Review of Pharmacology·A L Bassett, B F HOFFMAN
Dec 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·J C RoseP A Kot
Jun 1, 1973·Journal of Molecular and Cellular Cardiology·A F WillerbrandsS J Tasseron
Dec 1, 1973·European Journal of Pharmacology·V KecskemètiJ Knoll
Mar 15, 1974·Experientia·J BorbolaL Szekeres
May 1, 1972·European Journal of Pharmacology·W G ZijlstraA J Vergroesen
Apr 1, 1970·Circulation Research·A H HendersonE H Sonnenblick
Nov 1, 1964·The American Journal of Medicine·B F HOFFMAN, P F CRANEFIELD

Citations

Oct 1, 1990·Pflügers Archiv : European journal of physiology·G S FluriR Weingart
Nov 1, 1979·Prostaglandins and Medicine·K L BlackW E Lands
Sep 1, 1980·Acta Pharmacologica Et Toxicologica·E L PuistoP Eränkö

Related Concepts

Nerve Impulses
Metazoa
Eicosatetraenoic Acids
Felis catus
Saturated Fat
Heart
Osmosin
Myocardial Contraction
Prostaglandins E
Structure-Activity Relationship

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.