Activatable molecular agents for cancer theranostics.

Chemical Science
Jianjian ZhangKanyi Pu

Abstract

Theranostics that integrates diagnosis and treatment modalities has attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome. Such a theranostic paradigm requires agents to simultaneously possess the capabilities of targeting, imaging, and treatment. Activatable molecular agents (AMAs) are promising for cancer theranostics, as they show a higher signal-to-noise ratio (SNR), real-time detection of cancer-associated biomarkers, lower normal tissue toxicity, and a higher therapeutic effect. This perspective summarizes the recent advancements of AMAs, which include imaging-guided chemotherapy, imaging-guided photodynamic therapy, and imaging-guided photothermal therapy. The molecular design principles, theranostic mechanisms, and biomedical applications of AMAs are described, followed by a discussion of potential challenges of AMAs in cancer theranostics.

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Citations

Jun 18, 2021·Chemical Communications : Chem Comm·Kaiye WangBo Tang
Jun 24, 2021·ACS Applied Materials & Interfaces·Zhongrui ChenOlivier Siri
May 27, 2020·Chemical Society Reviews·Chi Zhang, Kanyi Pu
Mar 30, 2021·Materials Horizons·Zhen YangXiaoyuan Chen
Nov 1, 2020·Nanomaterials·Thabang C LebepeOluwatobi S Oluwafemi
Nov 4, 2020·Biomedical Materials·Yan XuBingbo Zhang
Jan 1, 2021·ACS Applied Materials & Interfaces·Tao GuoGuoming Huang
Nov 11, 2021·Biomaterials Science·Bing-De ZhengMei-Tian Xiao
Nov 5, 2021·Macromolecular Bioscience·Chengbin YangChih-Kuang Chen

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Methods Mentioned

BETA
surgical resection
imaging techniques
fluorescence imaging
fluorescence imaging technique
Confocal microscopy
electron exchange

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