Activatable Molecular Probes for Second Near-Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging.

Angewandte Chemie
Jiaguo Huang, Kanyi Pu

Abstract

Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence in biological tissue between 650-900 nm, conventional optical imaging often has a poor signal-to-background ratio and shallow penetration depth, which limits its ability in deep-tissue in vivo imaging. Second near-infrared fluorescence, chemiluminescence, and photoacoustic imaging modalities mitigate these issues by their respective advantages of minimized light scattering, eliminated external excitation, and ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the ability to change their second near-infrared fluorescence, chemiluminescence, or photoacoustic signals in response to a biomarker have been developed. This Minireview summarizes the molecular design strategies, sensing mechanisms, and imaging applications of AMPs. The potential challenges and perspectives of AMPs in deep-tissue imaging are also discussed.

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Citations

Oct 2, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qi ChenRuiping Zhang
Aug 12, 2020·Biomaterials Science·Ye YuanChangfeng Wu
Nov 28, 2020·Chemical Society Reviews·Cheng Xu, Kanyi Pu
Nov 27, 2020·Advanced Healthcare Materials·Miffy Hok Yan ChengGang Zheng
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Jun 10, 2020·Angewandte Chemie·Wenhan XuBen Zhong Tang
Nov 4, 2020·Biomedical Materials·Yan XuBingbo Zhang
Dec 11, 2020·Accounts of Chemical Research·Wenbo HuWei Huang
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Mar 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hui-Chao ZhouZonghai Sheng
Apr 27, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Tianran WangNao Xiao
Mar 28, 2021·Analytical and Bioanalytical Chemistry·Zece ZhuJintao Zhu
Apr 30, 2021·Biomedical Materials·Shanni HongYi Lu
Jun 24, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Dipendra DahalDipanjan Pan
Jul 11, 2021·Biosensors & Bioelectronics·Jinya DuHaifeng Dong

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