Activatable Nanocomposite Probe for Preoperative Location and Intraoperative Navigation for Orthotopic Hepatic Tumor Resection via MSOT and Aggregation-Induced Near-IR-I/II Fluorescence Imaging

Analytical Chemistry
Zhuo ZengShuizhu Wu

Abstract

The precise location of tumor and completeness of surgical resection are critical to successful tumor surgery; thus, the method capable of preoperatively locating a tumor site and intraoperatively determining tumor margins would be highly ideal. Herein, an activatable nanocomposite probe was developed for preoperatively locating orthotopic hepatic tumor via multispectral optoacoustic tomography imaging and for intraoperative navigation via near-IR-1 (NIR-I) and NIR-II fluorescence imaging. The molecular probe comprises an electronic donor, an acceptor, and a recognition moiety and forms the nanocomposite probe with bovine serum albumin. The probe specifically responds to nitroreductase overexpressed in tumor cells, which transforms the aromatic nitro group into an electron-donating amino group and thus activates the probe. The activated probe with the aggregation-induced emission feature generates strong NIR-I/NIR-II fluorescence and optoacoustic signals for dual-mode imaging. Owing to the in situ response toward nitroreductase in tumor cells in the hepatic region, the probe is found capable of detecting early stage orthotopic liver tumors. Furthermore, with the nanocomposite probe, we can obtain the 3D MSOT images to accuratel...Continue Reading

References

Oct 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nathan J Coombs, John Boyages
Jun 23, 2006·American Journal of Epidemiology·Heather A BoydMads Melbye
Jun 15, 2007·Journal of Cellular Physiology·George K Michalopoulos
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Quyen T NguyenRoger Y Tsien
Apr 15, 2010·Chemical Reviews·Vasilis Ntziachristos, Daniel Razansky
Dec 9, 2010·The Oncologist·Sheng-Long YeJean-Pierre Bronowicki
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Jul 9, 2011·Nature Protocols·Daniel RazanskyVasilis Ntziachristos
May 2, 2012·Physics in Medicine and Biology·Oscar R BrouwerFijs W B van Leeuwen
Jun 30, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alessandro CucchettiAntonio D Pinna
May 16, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stijn KeereweerClemens W G M Löwik
Mar 5, 2014·The British Journal of Radiology·S R McKeown
Sep 10, 2014·Journal of the American Chemical Society·Palapuravan AneesAyyappanpillai Ajayaghosh
Jan 18, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yi-Nan ZhangWarren C W Chan
Apr 6, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jessica L PetrickPhilip S Rosenberg
Jun 30, 2016·Nature Reviews. Gastroenterology & Hepatology·Stuart J Forbes, Philip N Newsome
Jul 29, 2016·Nature Methods·Judith WeberSarah E Bohndiek
Oct 28, 2016·Journal of Hepatocellular Carcinoma·Julius BaloghHoward P Monsour
Dec 21, 2016·Liver Cancer·Masatoshi KudoLorenza Rimassa
Mar 6, 2017·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Jonathon WillattF Syed
Sep 1, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lewis R RobertsKhaled Mohammed
Nov 9, 2017·Nature Reviews. Clinical Oncology·Ibiayi Dagogo-Jack, Alice T Shaw
May 2, 2018·The American Journal of Gastroenterology·Ruben Hernaez, Hashem B El-Serag
Jun 26, 2018·Journal of Surgical Oncology·Labrinus van ManenJan Sven David Mieog
Apr 27, 2019·Advanced Materials·Shoujun ZhuHongjie Dai

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Citations

Mar 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lixiu ChenZhengbao Zha
Jun 16, 2021·Journal of Pharmaceutical and Biomedical Analysis·Jian QiaoDahong Li
Jul 29, 2021·Chemical Communications : Chem Comm·Xiaofan ZhangHuimin Ma
Aug 21, 2021·Advanced Healthcare Materials·Jun DaiShixuan Wang

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