PMID: 9636964Jun 24, 1998Paper

Activated and total coagulation factor VII, and fibrinogen in coronary artery disease

Scandinavian Cardiovascular Journal : SCJ
R DanielsenJ H Morrissey

Abstract

Fibrinogen (FBG) and total coagulation factor VII (FVIIc) concentrations are higher in those patients with coronary artery disease who are at increased future risk of acute ischemic events. The relationship between activated factor VII (FVIIa) and cardiovascular events, however, has not been intensively studied. Data were collected from 401 consecutive patients who underwent coronary angiography because of suspected coronary artery disease. Conventional risk factors FVIIc, FVIIa and FBG were assessed in relation to the severity of coronary artery disease, left ventricular ejection fraction, and previous clinical events. A strong positive correlation was found between FVIIa and FVIIc (p < 0.001), but neither FVIIa nor FVIIc correlated with FBG. No correlation was found between FVIIa, FVIIc or FBG levels and stenosis score for the severity of coronary artery disease, and all were similar in patients with stable or unstable angina pectoris. Multivariate regression analysis showed FVIIc to be higher in women (p = 0.004), and positively related to triglycerides (p = 0.001) and HDL cholesterol (p = 0.006), but not to a previous myocardial infarction or total cholesterol. FVIIa, on the other hand, was lower in patients with a previous...Continue Reading

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Citations

Feb 13, 2001·European Journal of Clinical Investigation·B MüllerG A Marbet
May 29, 2015·Critical Reviews in Biochemistry and Molecular Biology·Stephanie A SmithJames H Morrissey
Dec 13, 2006·Journal of Thrombosis and Haemostasis : JTH·J Vermylen, M F Hoylaerts
Oct 5, 2010·Acta Anaesthesiologica Scandinavica·H R ThorarinsdottirG H Sigurdsson
Dec 1, 2006·Acta Haematologica·Rolf JordeJohn-Bjarne Hansen
Feb 15, 2017·Journal of Clinical Laboratory Analysis·Takuya ShiraishiEiji Kajii
Dec 22, 1999·The Journal of International Medical Research·A AltinbaşS Kirazli
Apr 18, 2002·International Journal of Cardiology·Maciej GilJerzy Adamus

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