Activated caspase-1 is not a central mediator of inflammation in the course of ischemia-reperfusion

Transplantation
M A DaemenW A Buurman

Abstract

Upon transplantation, donor organs subjected to prolonged ischemia suffer from reperfusion injury. Recent observations suggest that caspase activation is involved in inducing the deleterious inflammatory reaction that mediates reperfusion injury. Release of cytokines like interleukin (IL)-1 and IL-18 may occur during apoptosis through activation of caspase-1/IL-1beta-converting enzyme. We hypothesized that caspase-1 activation is a key event in apoptosis/ caspase-dependent inflammation during the development of renal reperfusion injury. Caspase-1-/-, caspase-1+/+ as well as Swiss mice were subjected to 45 min of renal ischemia and 24 hr of reperfusion. Animals were administered agents capable of neutralizing the pro-inflammatory activation products of caspase-1 (IL-1 receptor antagonist, anti-IL-1 receptor antibody, and anti-IL-18 antibody). The extent of renal functional deterioration, inflammation, and apoptosis were compared. No improvement in renal function as reflected by serum ureum and creatinine were found in caspase-1-/- mice as compared to wild type controls. Caspase-1-/- mice showed slightly attenuated renal inflammation as indicated by decreased renal neutrophil influx, but failed to show changes in intrarenal tumor...Continue Reading

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Citations

Sep 19, 2003·Seminars in Nephrology·Gur P Kaushal
Jun 27, 2002·Transplantation·Marc A R C DaemenWim A Buurman
May 1, 2002·Current Opinion in Nephrology and Hypertension·Ramon Bonegio, Wilfred Lieberthal
Aug 19, 2003·Transplantation·Jens LutzUwe Heemann
Jun 29, 2007·American Journal of Nephrology·Bin YangMichael L Nicholson
Sep 26, 2008·Journal of the American Society of Nephrology : JASN·Huiling WuSteven J Chadban
Jul 16, 2004·Kidney International·Gur P KaushalSudhir V Shah
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Jul 30, 2005·World Journal of Gastroenterology : WJG·Yong-Jie YangXi-Rui Ge
Oct 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alana A ShigeokaDianne B McKay
Mar 7, 2003·American Journal of Physiology. Renal Physiology·Babu J Padanilam

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