PMID: 9529329May 16, 1998Paper

Activated complement component 3 (C3) is required for ultraviolet induction of immunosuppression and antigenic tolerance

The Journal of Experimental Medicine
C HammerbergK D Cooper

Abstract

Complement component 3 (C3), a critical regulator of innate immunity, may also play a role in the regulation of cognate immunity, such as contact sensitivity responses. Because ultraviolet (UV) radiation also activates C3 in the skin, we determined whether the immunosuppressed state that results when a contact sensitizer is applied through UVB-exposed skin requires the presence and activation of C3. This question was addressed through the use of C3-deficient mice, blockade of C3 cleavage to C3b, and accelerated degradation of iC3b by soluble complement receptor 1 (sCR1). Both C3-modulated systems totally reversed the failure to induce a contact sensitivity response to dinitrofluorobenzene (DNFB) upon primary sensitization at the UV-exposed site, as well as immunologic tolerance to a second DNFB immunization through normal skin. Treatment with sCR1 reduced the infiltration of CD11b+ leukocytes into the epidermis and dermis of UV-irradiated skin but did not reverse the UV-induced depletion of epidermal class II MHC+CD11blo Langerhans cells. These data, taken together with previous results showing abrogation of locally induced UV immunosuppression by in vivo anti-CD11b treatment, suggest a novel mechanism by which ligation of the ...Continue Reading

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Citations

Jan 26, 2002·Journal of Photochemistry and Photobiology. B, Biology·S K KatiyarC A Elmets
Sep 17, 2002·Methods : a Companion to Methods in Enzymology·Eiko ToichiKevin D Cooper
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