Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery

AIDS
Birgitte StiksrudAnne M Dyrhol-Riise

Abstract

To explore monocyte and dendritic cell immune responses, and their association with future CD4 gain in treated HIV patients with suboptimal CD4 recovery. A cross-sectional study of HIV-infected, virally suppressed individuals on antiretroviral therapy for at least 24 months; 41 immunological nonresponders (INRs) (CD4 cell count <400 cells/μl) and 26 immunological responders (CD4 cell count >600 cells/μl). Ten HIV-infected antiretroviral therapy-naive and 10 HIV-negative healthy persons served as controls. CD4 cell counts were registered after median 2.4 and 4.7 years. Monocyte, dendritic-cell and T-cell activation and regulatory T cells (Tregs) were analyzed by flow cytometry. In INR and immunological responder subgroups matched on age and nadir CD4 cell count, upregulation of interferon-inducible protein-10 (IP-10) and indoleamine 2,3-dioxygenase in monocytes and dendritic cells and cytokines in cell supernatants were measured in vitro in peripheral blood mononuclear cells stimulated with aldrithiol-2-inactivated HIV-1. The INR group displayed higher spontaneous activation of both monocytes (HLA-DR) and myeloid and plasmacytoid dendritic cells (HLA-DR, CD83 and CD86) compared with immunological responders, and this was associa...Continue Reading

References

Apr 2, 2003·Virology·Brian R LaneDavid M Markovitz
Jul 12, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gilbert R KaufmannUNKNOWN Swiss HIV Cohort Study
Aug 5, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Melissa Farmer MillerChristopher F Rowley
Nov 23, 2006·Nature Medicine·Jason M BrenchleyDaniel C Douek
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jihed ChehimiLuis J Montaner
Nov 6, 2007·Immunological Reviews·Osamu Takeuchi, Shizuo Akira
Sep 9, 2008·The Journal of Clinical Investigation·Olivier ManchesNina Bhardwaj
Feb 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Colleen F KelleySteven G Deeks
Apr 30, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Alexander Rölle, Johanna Olweus
Jul 6, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kenneth A LichtensteinUNKNOWN HIV Outpatient Study (HOPS) Investigators
Aug 10, 2010·Blood·Rachel Lubong SabadoNina Bhardwaj
Feb 26, 2011·Nature Reviews. Immunology·Marcus AltfeldNina Bhardwaj
Aug 14, 2012·Nature Reviews. Microbiology·Netanya G Sandler, Daniel C Douek
Jun 19, 2013·Immunological Reviews·Elizabeth Miller, Nina Bhardwaj
Dec 29, 2013·AIDS·Jason V BakerUNKNOWN CDC SUN Study Investigators
Jan 25, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frederik N EngsigUNKNOWN Antiretroviral Therapy Cohort Collaboration (ART-CC) and the Collaboration of Observational HIV Epidemiological Research Eur
Apr 24, 2014·The Journal of Infectious Diseases·Peter W HuntMichael M Lederman
May 13, 2014·The Journal of Infectious Diseases·Eleanor M P WilsonUNKNOWN Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN Study) Investigators
Mar 21, 2015·The Journal of Infectious Diseases·Eleanor M P WilsonJason V Baker
Dec 2, 2015·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·UNKNOWN Late presenters working group in COHERE in EuroCoordOle Kirk

❮ Previous
Next ❯

Citations

Dec 4, 2019·Current Opinion in Infectious Diseases·Dag Henrik ReikvamBirgitte Stiksrud
Oct 18, 2020·AIDS Research and Human Retroviruses·Eric G MeissnerNetanya S Utay
Nov 27, 2020·Frontiers in Immunology·Isaac Rosado-SánchezYolanda María Pacheco

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
flow cytometry

Software Mentioned

FlowJo
GraphPad Prism
SPSS

Related Concepts

Related Feeds