PMID: 8946212Oct 1, 1996Paper

Activated gamma/delta T lymphocytes infiltrating renal cell carcinoma

Immunology Letters
D KowalczykJ Nowak

Abstract

Gamma/delta (gamma delta) T lymphocytes have been postulated to play a role in a surveillance mechanism that eliminates transformed or otherwise damaged cells. In this study, we examined by flow cytometry the frequency and phenotype of gamma delta T cells in the tumour infiltrating lymphocytes (TIL) and peripheral blood (PBL) from renal cell carcinoma patients. The TCR gamma delta + cells comprised an average of 3.8% of the CD3+ TIL and 5.2% of circulating T cells. Analysis of surface immunophenotype revealed that activation markers of T lymphocytes: CD25 and HLA DR were highly expressed on the tumour infiltrating gamma delta + T lymphocytes (median 27.6% for CD25 and 52.0% for HLA DR). More importantly, percentage of activated gamma delta T cells was found to be much higher than compared to all activated CD3+ cells. Furthermore, an unusually high proportion of gamma delta positive TILs express CD4 or CD8 molecules (17.2 and 36.8%, respectively), indicating that they might recognise antigen presented within MHC II or I context. These results suggest that gamma delta T lymphocytes may play a certain role in immune response against tumour cells.

References

Jun 30, 1988·Nature·C A Janeway
Jun 1, 1985·The Journal of Experimental Medicine·M KrönkeW C Greene
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SpanerR A Phillips

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Citations

Aug 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·N Seo, Y Tokura
Jun 5, 2010·PLoS Pathogens·Rabinarayan MishraEva Szomolanyi-Tsuda
Nov 11, 2015·Veterinary Immunology and Immunopathology·Maria BraukmannAngela Berndt
Aug 28, 2007·Journal of Dermatological Science·Naohiro Seo, Masahiro Takigawa
May 26, 2009·Immunology Letters·Ludovic MartinetJean-Jacques Fournié
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brant A InmanEugene D Kwon
Sep 26, 2020·Frontiers in Immunology·Nadine LehmannJoerg Faber

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