Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma

JCI Insight
Anna K SchergerUlrich Keller

Abstract

Aberrant activity of the glycoprotein 130 130/JAK/STAT3 (gp130/JAK/STAT3) signaling axis is a recurrent event in inflammation and cancer. In particular, it is associated with a wide range of hematological malignancies, including multiple myeloma and leukemia. Novel targeted therapies have only been successful for some subtypes of these malignancies, underlining the need for developing robust mouse models to better dissect the role of this pathway in specific tumorigenic processes. Here, we investigated the role of selective gp130/JAK/STAT3 activation by generating a conditional mouse model. This model targeted constitutively active, cell-autonomous gp130 activity to B cells, as well as to the entire hematopoietic system. We found that regardless of the timing of activation in B cells, constitutively active gp130 signaling resulted in the formation specifically of mature B cell lymphomas and plasma cell disorders with full penetrance, only with different latencies, where infiltrating CD138+ cells were a dominant feature in every tumor. Furthermore, constitutively active gp130 signaling in all adult hematopoietic cells also led to the development specifically of largely mature, aggressive B cell cancers, again with a high penetra...Continue Reading

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Citations

Nov 7, 2019·Cancers·Neele Schumacher, Stefan Rose-John
May 29, 2021·Seminars in Immunopathology·Dirk Schmidt-ArrasStefan Rose-John
Jun 19, 2021·Frontiers in Cell and Developmental Biology·Dirk Schmidt-Arras, Stefan Rose-John

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Datasets Mentioned

BETA
GSE132148

Methods Mentioned

BETA
flow cytometry
electrophoresis
RNA-Seq
transgenic

Software Mentioned

GraphPad Prism
Excel

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