PMID: 8598231Mar 1, 1996Paper

Activated human platelets express beta2 integrin

European Journal of Haematology
M M PhilippeauxP F Piguet

Abstract

The expression of molecules of the beta2 integrin family (CD11a, CD11b , CD11c, and CD18) was explored on 2 human megakaryocytic cell lines and on platelets from different donors by immunofluorescence and flow cytometry using a large panel of mAb. CD11a, CD11b, CD11c and CD18 were detected on the megakaryocytic cell lines DAMI and HEL. A low and variable expression of CD11a, CD11b and CD18 determinants was also detected on resting platelets; this expression was markedly increased when platelets were activated by thrombin. Expression of CD18 was closely correlated to that of CD11a or CD11b when comparing the fluorescence intensity observed in different experiments. In presence of Ca++, platelets did bind to a RAJI cell line which exhibits a high expression level of CD54. This binding was increased when platelets were activated by thrombin and was decreased by an anti CD11a, CD18 and anti CD54 mAb. This study indicates that human platelets express molecules of the beta2 integrin family, when activated, which allows them to bind to CD54 bearing cells.

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Citations

Jul 3, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·D FirminL Misery
Dec 21, 2000·Parasite Immunology·D MazierM Idrissa-Boubou
Jan 14, 2005·The Keio Journal of Medicine·Lawrence L HorstmanYeon S Ahn
Jan 11, 2011·Expert Opinion on Drug Safety·Marina TalamontiSergio Chimenti
Apr 8, 1998·British Journal of Haematology·J Guo, P F Piguet
Apr 24, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·David E AllisonJudith A Fox
Oct 13, 2006·The British Journal of Dermatology·W L TomJ M Obadiah
Jan 18, 2020·International Journal of Molecular Sciences·David R J RileyFrancisco Rivero
Oct 15, 2014·Antioxidants & Redox Signaling·Ronit Mor-Cohen
May 8, 1999·Journal of Diabetes and Its Complications·G FontanaD Fedele
Aug 10, 1999·Critical Reviews in Oncology/hematology·L L Horstman, Y S Ahn
Jul 25, 2021·International Journal of Molecular Sciences·Angie De La CruzRolando E Rumbaut
May 15, 2007·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·F CognasseO Garraud

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