Activated macrophages in human periodontitis

Journal of Periodontology
J CharonA W Gargiulo

Abstract

Fifteen patients, eight males and seven females, ranging from 30 to 88 years of age with advanced periodontal disease were selected for this study. Biopsies and blood samples were taken of both normal and inflamed gingival tissues, and processed for detection of nonspecific esterase and acid phosphatase activity in monocytes and macrophages. Activated macrophages, as indicated by their intense reaction to acid phosphatase and nonspecific esterase, were found in the gingival epithelium, lamina propria, perivascular tissues and in the blood vessels in human chronic periodontitis. Blood smears of monocytes showed variability of stain intensity suggesting that their activation occurred in blood vessels where they marginate and emigrate into the perivascular tissues in chronic periodontitis. They then appear as macrophages that migrate through the connective tissue, penetrate the basement membrane and continue through the epithelium. The nonspecific esterase stain identified T-cells, by a singular dot-like granule, and plasma cells by multiple granules in the cytoplasm. Lymphocytes containing multiple cytoplasmic nonspecific esterase positive granules commonly were found only in the perivascular connective tissue and may represent B...Continue Reading

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Citations

May 20, 2014·Current Oral Health Reports·Nasi Huang, Frank C Gibson
Sep 1, 2005·Journal of Clinical Periodontology·Tord Berglundh, Mauro Donati
Feb 26, 2011·Journal of Clinical Periodontology·Amedeo IndrioloStefano Fagiuoli
Feb 26, 2011·Journal of Clinical Periodontology·Tord BerglundhMauro Donati
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Jun 25, 2016·Archives of Oral Biology·Ping ZhangYun Feng
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Apr 20, 2017·International Journal of Molecular Sciences·Yosuke ShikamaMakoto Funaki
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Mar 7, 2018·Journal of Immunology Research·Luca ParisiLorenzo Mortara

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