Activated microglia contribute to convergent nociceptive inputs to spinal dorsal horn neurons and the development of neuropathic pain

Neurochemical Research
Yuya YamamotoTomosada Sugimoto

Abstract

The activation of microglia in the spinal dorsal horn following peripheral nerve injury has been reported previously, and this change has been proposed to contribute to the development of a neuropathic pain state. We recently demonstrated that peripheral nerve injury activated convergent nociceptive inputs to spinal dorsal horn neurons. The present study was designed to further examine the role of microglia in the activation of convergent nociceptive inputs as well as development of a neuropathic pain state after peripheral nerve injury. Tibial nerve injury initially induced hyposensitivity at 3 days post-injury, and this was followed by hypersensitivity to tactile and thermal stimuli at 14 days. The intraperitoneal administration of minocycline (30 mg/kg), an inhibitor of microglial activation, for 8 days starting on the day of surgery prevented increases in OX-42 immunofluorescence labeling in the spinal dorsal horn and the development of tactile and thermal hypersensitivity at 14 days post-injury. The same minocycline treatment (day 0-7) also reduced the nerve injury-induced convergence of nociceptive inputs to spinal dorsal horn neurons, as revealed by double immunofluorescence labeling for c-Fos induced by noxious heat sti...Continue Reading

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Citations

Dec 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ihsan Ekin DemirGüralp O Ceyhan
Nov 16, 2016·The International Journal of Neuroscience·Yuchao Shang, Yuying Tang
Sep 28, 2017·Neural Plasticity·Young S GwakJoong Woo Leem
Nov 1, 2017·PeerJ·Constanza Stefania MenesesMarianne Patricia Werner
Apr 23, 2017·Current Pain and Headache Reports·Kathleen MeachamSimon Haroutounian
Sep 19, 2017·The International Journal of Neuroscience·Mitsuyasu TabataTomosada Sugimoto
Jan 12, 2021·The International Journal of Neuroscience·Ryuji Terayama, Kenta Uchibe
Nov 28, 2019·British Journal of Anaesthesia·Mark WillinghamSimon Haroutounian
Mar 3, 2020·European Journal of Pharmacology·Thamyris Reis MoraesGiovane Galdino

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