Activated mouse T cells downregulate, process and present their surface TCR to cognate anti-idiotypic CD4+ T cells

Immunology and Cell Biology
Girdhari LalRabindranath Nayak

Abstract

The ability of activated T cells to present foreign antigens through the MHC class II pathway has been shown in the case of human, rat and mouse T cells. In the present study, the ability of activated T cells to present their endogenous TCR in association with MHC class II molecules to CD4+ T cells was shown. Upon activation mouse T cells downregulate their surface TCR, which are degraded into peptides in endosomal/lysosomal compartments. The idiopeptides (peptides derived from the variable region of the TCR) are presented to cognate anti-idiotypic CD4+ T cells, resulting in activation and proliferation of these cells. Interaction of idiotypic and anti-idiotypic T cells brought about by presentation of TCR idiopeptide may have important implications for T-cell vaccination and perpetuation of T-cell memory not requiring persisting antigen or long-lived memory cells.

References

Jul 1, 1985·The Journal of Cell Biology·J W ChenJ T August
Apr 1, 1987·The Journal of Experimental Medicine·M S Krangel
Mar 1, 1987·Annales De L'Institut Pasteur. Immunology·J H Russell, K M Coggeshall
Oct 21, 1986·Biochemistry·C T Zimmerle, C Frieden
Dec 1, 1985·Molecular Immunology·L GrafV Schirrmacher
Jan 1, 1994·European Journal of Immunology·V BarnabaA Lanzavecchia
Jun 1, 1994·The Journal of Experimental Medicine·Z Cai, J Sprent
Aug 1, 1996·Current Opinion in Cell Biology·M N SeamanS D Emr
Sep 1, 1996·European Journal of Immunology·S ValituttiA Lanzavecchia
Feb 17, 1997·The Journal of Experimental Medicine·Z CaiJ Sprent
Apr 29, 1998·European Journal of Immunology·R Hakamada-TaguchiH Nariuchi
May 23, 1998·Annual Review of Immunology·M M DavisY Chien
Feb 16, 1999·Cell·J M Penninger, G R Crabtree
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y C ZangJ Z Zhang
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L S CauleyS L Swain
May 1, 2001·Immunology·R NayakM S Shaila
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·F SebilleJ P Soulillou
Jul 14, 2001·Science·J Sprent, D F Tough
Dec 18, 2001·European Journal of Immunology·T KambayashiH G Ljunggren
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jes DietrichCarsten Geisler
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kahori KurosakaYoshiro Kobayashi
Feb 12, 2004·Autoimmunity Reviews·Anat Achiron, Mathilda Mandel
May 14, 2004·Journal of Virology·E John Wherry, Rafi Ahmed
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marina von EssenCarsten Geisler
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judie BoisvertMatthew F Krummel
Jun 4, 2005·Science·Marlène BrandesBernhard Moser
Jul 28, 2005·Microbes and Infection·Rabindranath NayakM S Shaila

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Citations

Aug 7, 2014·Clinical Reviews in Allergy & Immunology·Xin HuangQianjin Lu
Nov 29, 2005·Molecular Immunology·Girdhari LalRabindranath Nayak
Sep 24, 2013·Toxicon : Official Journal of the International Society on Toxinology·M KhoobdelS Akbari
Mar 29, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcia Arenas-HernandezNardhy Gomez-Lopez

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