Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis via COX-1.

Arteriosclerosis, Thrombosis, and Vascular Biology
Michael S GarshickJeffrey S Berger

Abstract

Patients with psoriasis have impaired vascular health and increased cardiovascular disease (CVD). Platelets are key players in the pathogenesis of vascular dysfunction in cardiovascular disease and represent therapeutic targets in cardiovascular prevention. The object of this study was to define the platelet phenotype and effector cell properties on vascular health in psoriasis and evaluate whether aspirin modulates the platelet-induced phenotype. Approach and Results: Platelets from psoriasis patients (n=45) exhibited increased platelet activation (relative to age- and gender-matched controls, n=18), which correlated with psoriasis skin severity. Isolated platelets from psoriasis patients demonstrated a 2- to 3-fold (P<0.01) increased adhesion to human aortic endothelial cells and induced proinflammatory transcriptional changes, including upregulation of IL 8 (interleukin 8), IL1β, and Cox (cyclooxygenase)-2 Platelet RNA sequencing revealed an interferon signature and elevated expression of COX-1, which correlated with psoriasis disease severity (r=0.83, P=0.01). In a randomized trial of patients with psoriasis, 2 weeks of 81 mg low-dose aspirin, a COX-1 inhibitor, reduced serum thromboxane (Tx) B2 and reduced brachial vein en...Continue Reading

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Citations

Jan 15, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Joseph E Aslan
Dec 2, 2020·Journal of the American Academy of Dermatology·Youssef A ElnabawiJeffrey S Berger
Mar 26, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Shigeo GodoHiroaki Shimokawa
Apr 3, 2021·Journal of the American College of Cardiology·Michael S GarshickJeffrey S Berger
Apr 4, 2021·The Journal of Investigative Dermatology·Franziska HersterAlexander N R Weber
Jun 11, 2021·Circulation Research·Meaghan E CollingYogendra Kanthi
Sep 2, 2021·Current Atherosclerosis Reports·Brittany WeberMichael S Garshick

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Methods Mentioned

BETA
ELISA
scanning electron microscopy
flow cytometry
biopsies
Flow

Software Mentioned

Ingenuity Pathway Analysis
ImageJ
Stata
R
Power
Olink

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