Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung

The Journal of Allergy and Clinical Immunology
Katharina JandlAkos Heinemann

Abstract

Prostaglandin (PG) D2 is an early-phase mediator in inflammation, but its action and the roles of the 2 D-type prostanoid receptors (DPs) DP1 and DP2 (also called chemoattractant receptor-homologous molecule expressed on T(H)2 cells) in regulating macrophages have not been elucidated to date. We investigated the role of PGD2 receptors on primary human macrophages, as well as primary murine lung macrophages, and their ability to influence neutrophil action in vitro and in vivo. In vitro studies, including migration, Ca(2+) flux, and cytokine secretion, were conducted with primary human monocyte-derived macrophages and neutrophils and freshly isolated murine alveolar and pulmonary interstitial macrophages. In vivo pulmonary inflammation was assessed in male BALB/c mice. Activation of DP1, DP2, or both receptors on human macrophages induced strong intracellular Ca(2+) flux, cytokine release, and migration of macrophages. In a murine model of LPS-induced pulmonary inflammation, activation of each PGD2 receptor resulted in aggravated airway neutrophilia, tissue myeloperoxidase activity, cytokine contents, and decreased lung compliance. Selective depletion of alveolar macrophages abolished the PGD2-enhanced inflammatory response. Act...Continue Reading

References

Mar 1, 1989·British Journal of Pharmacology·R A Coleman, R L Sheldrick
Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·Y KubotaM Nakagawa
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philippe GossetFrançois Trottein
May 5, 2004·Best Practice & Research. Clinical Rheumatology·Jean-Michel Dayer
Nov 6, 2004·The Journal of Pharmacology and Experimental Therapeutics·Yoshiki ShiraishiAkitoshi Ishizaka
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Isabelle SpikDavid Dombrowicz
Jun 24, 2005·Respiratory Research·Beatrice Beck-SchimmerRalph C Schimmer
Oct 8, 2005·The Journal of Allergy and Clinical Immunology·Akos HeinemannAdele Hartnell
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takahiro SatohMasataka Nakamura
Jan 16, 2008·Current Opinion in Critical Care·Nikolaos A Maniatis, Stylianos E Orfanos
May 21, 2008·Blood·Oliver SoehnleinLennart Lindbom
May 22, 2008·The Journal of Pharmacology and Experimental Therapeutics·Tsuyoshi TajimaMasatoshi Hori
Jan 16, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Elizabeth R Johnson, Michael A Matthay
Sep 4, 2010·American Journal of Respiratory and Critical Care Medicine·Silvana BalzarSally E Wenzel
Mar 3, 2011·Cellular and Molecular Life Sciences : CMLS·Petra Luschnig-SchratlAkos Heinemann
Apr 9, 2011·American Journal of Respiratory and Critical Care Medicine·Fang-Fang HuangHomayoun Shams
May 3, 2011·American Journal of Respiratory Cell and Molecular Biology·Gustavo Matute-BelloUNKNOWN Acute Lung Injury in Animals Study Group
Jul 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N BarnesC M Perkins
Sep 21, 2011·The Journal of Allergy and Clinical Immunology·Miriam SedejMaria Waldhoer
Jan 24, 2012·Bioorganic & Medicinal Chemistry Letters·Jiwen Jim LiuJulio C Medina
Apr 13, 2012·The European Respiratory Journal·Dave SinghBrian O'Connor
Jan 1, 2011·Frontiers in Immunology·Susanne HeroldJuergen Lohmeyer
Jul 24, 2012·American Journal of Respiratory and Critical Care Medicine·Kevin DhaliwalA John Simpson
Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Takahisa MurataHiroshi Ozaki
Mar 20, 2013·The Journal of Allergy and Clinical Immunology·Merritt L FajtSally E Wenzel
Dec 4, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hana SarashinaTakahisa Murata
Apr 16, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Viktoria KonyaAkos Heinemann
Apr 22, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yoko ItoRobert J Mason
Jun 15, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva M SturmRudolf Schicho
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Luzheng XuePaul Klenerman

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Citations

Jul 14, 2016·Expert Opinion on Investigational Drugs·Pierachille Santus, Dejan Radovanovic
Oct 16, 2016·The Journal of Nutritional Biochemistry·Sergio Montserrat-de la PazFrancisco J G Muriana
May 2, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshitaka Taketomi, Makoto Murakami
Jun 21, 2017·The Journal of Allergy and Clinical Immunology·Yufeng ZhouPeisong Gao
Dec 5, 2018·Expert Opinion on Investigational Drugs·Giancarlo MaroneGilda Varricchi
Sep 10, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Dongdong ChaiHong Jiang
Aug 13, 2017·Scientific Reports·Thomas BärnthalerAkos Heinemann
Sep 21, 2018·Frontiers in Immunology·Nincy Debeuf, Bart N Lambrecht
Aug 31, 2017·Scientific Reports·Aswin HariHsiao-Huei Chen
Jan 19, 2018·Molecular Medicine Reports·Wei LeiJianan Huang
Sep 12, 2020·Cell Research·Shuai MaGuang-Hui Liu
Dec 9, 2017·Journal of Lipid Research·Priscilla A T PereiraLúcia H Faccioli
Aug 5, 2017·Frontiers in Medicine·Miriam PeinhauptAkos Heinemann
Nov 9, 2020·The Lancet. Respiratory Medicine·Huib A M Kerstjens, Reinoud Gosens
Nov 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joan Serrano-MarínRafael Franco
May 21, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wentao ChenLuzheng Xue
Jul 26, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Ian VargasSamuel A Wickline
May 29, 2019·International Archives of Allergy and Immunology·Gilda VarricchiGianni Marone
Oct 11, 2020·Biochemical Pharmacology·Sonja RittchenAkos Heinemann

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Methods Mentioned

BETA
bronchoalveolar lavage
protein assay
ELISA

Software Mentioned

GraphPad
GraphPad Prism

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