Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside

International Journal of Molecular Sciences
Ruilong ZhaoMeilang Xue

Abstract

Independent of its well-known anticoagulation effects, activated protein C (APC) exhibits pleiotropic cytoprotective properties. These include anti-inflammatory actions, anti-apoptosis, and endothelial and epithelial barrier stabilisation. Such beneficial effects have made APC an attractive target of research in a plethora of physiological and pathophysiological processes. Of note, the past decade or so has seen the emergence of its roles in cutaneous wound healing-a complex process involving inflammation, proliferation and remodelling. This review will highlight APC's functions and mechanisms, and detail its pre-clinical and clinical studies on cutaneous wound healing.

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Citations

Jul 28, 2019·Current Opinion in Hematology·Laurent O Mosnier
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Nov 16, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Julia OtoPilar Medina
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Methods Mentioned

BETA
glycosylation
PCR
biopsies

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