PMID: 9423813Jan 10, 1998Paper

Activated protein C resistance and the factor V Leiden mutation in children with thrombosis

American Journal of Hematology
M T SifontesM J Manco-Johnson

Abstract

To determine the prevalence of activated protein C resistance and the factor V Leiden mutation (position 1691, arginine 506 to glutamine substitution) in children with thrombosis, plasma samples from children with thrombosis were tested for activated protein C resistance. DNA was analyzed for the factor V Leiden mutation. Five of 34 children (15%) had activated protein C resistance; each was heterozygous for the factor V Leiden mutation. All 5 children heterozygous for the factor V Leiden mutation suffered non-CNS venous thromboses comprising 21% of the group of children (5/24) with non-CNS venous thrombotic events. Each of these 5 children had a family history of thrombosis. In conclusion, children with non-CNS venous thrombosis should be evaluated for the factor V Leiden mutation. Children most likely affected are those with a family history of thrombosis.

References

Feb 24, 1994·The New England Journal of Medicine·P J Svensson, B Dahlbäck
Mar 1, 1996·British Journal of Haematology·U Nowak-GöttlR Schneppenheim
Mar 1, 1996·The Journal of Pediatrics·M T SifontesM J Manco-Johnson

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Citations

Sep 11, 2012·Best Practice & Research. Clinical Haematology·Gili Kenet, Ulrike Nowak-Göttl
Feb 7, 2001·Chest·P MonagleM Andrew
Aug 13, 2011·Seminars in Fetal & Neonatal Medicine·Ulrike Nowak-GöttlGili Kenet
Jan 5, 2002·Emergency Medicine Clinics of North America·S E Farrell
Oct 30, 2004·Hematology/oncology Clinics of North America·Janna M Journeycake, Marilyn J Manco-Johnson
Jan 5, 2002·American Journal of Hematology·R S Robetorye, G M Rodgers
Jan 1, 2005·Pediatric Hematology and Oncology·Hale OrenAytemiz Gürgey
Oct 19, 2000·Journal of Pediatric Hematology/oncology·K J BroxtermanL Chicoine
Oct 5, 2001·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M MoussalemJ F Schvedjf
Nov 8, 2002·Archives of Pathology & Laboratory Medicine·Richard D PressJohn A Heit

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