Activated prothrombin complex concentrate (FEIBA) treatment during surgery in patients with inhibitors to FVIII/IX: the updated Norwegian experience

Haemophilia : the Official Journal of the World Federation of Hemophilia
G E Tjønnfjord

Abstract

Non-activated and activated prothrombin complex concentrates have been used successfully to treat bleeds in haemophilia patients with inhibitors, but most physicians do not consider these products as effective as factor VIII/IX concentrates in non-inhibitor patients. Thus, surgical procedures in inhibitor patients have been performed reluctantly. We have performed 15 minor and six major surgical and invasive diagnostic or therapeutic procedures in eight inhibitor patients with congenital haemophilia A and in two patients with acquired haemophilia. Administration of a loading dose of 100 U kg(-1) of FEIBA followed by 200 U kg (-1) day(-1) in three doses every 8 h for 3 days and then tapering the daily dose to 150-100 U kg(-1), resulted in no severe or unexpected bleeding complications. One adverse event was observed. A 69-year-old man suffered a myocardial infarction the third postoperative day following sigmoidectomy. He was managed safely with opiate analgesia, nitrates and diuretics and the continued use of FEIBA.

References

Mar 1, 1978·American Journal of Diseases of Children·R H Yolken, M W Hilgartner
Apr 26, 2000·Haemophilia : the Official Journal of the World Federation of Hemophilia·I CohenA Chechick
Nov 2, 2002·Haemophilia : the Official Journal of the World Federation of Hemophilia·V MishraS Vaaler

❮ Previous
Next ❯

Citations

Jul 27, 2010·Expert Opinion on Emerging Drugs·Leonard A ValentinoMichele Grygotis
Nov 8, 2008·Expert Opinion on Biological Therapy·Rebecca Kruse-JarresCindy Leissinger
Sep 24, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-Merchan, A Rocino
Sep 1, 2005·Haemophilia : the Official Journal of the World Federation of Hemophilia·P A HolmeG E Tjønnfjord
Oct 13, 2005·Haemophilia : the Official Journal of the World Federation of Hemophilia·C Ludlam
Oct 27, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·L M Aledort
May 11, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·L P SolimenoE Santagostino
Nov 7, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Di PaolaC Leissinger
Apr 28, 2007·Journal of Thrombosis and Haemostasis : JTH·P W Collins
Oct 18, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-MerchanM Quintana
Jun 25, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·P CollinsC M Kessler
Aug 21, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·D M DiMicheleE Santagostino
Sep 21, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·E H KrautW-Y Wong
Aug 29, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·R Kulkarni
Aug 23, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·M MakrisR D'Oiron
Dec 24, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A Valentino
Apr 22, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Angela NotarnicolaBiagio Moretti
Nov 20, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·E Berntorp
Oct 10, 2009·British Journal of Haematology·Peter W Collins, Charles L Percy
Jul 21, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·S RangarajanJ Wilde
Aug 4, 2011·Journal of Thrombosis and Haemostasis : JTH·P W Collins
Sep 20, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·S RangarajanT T Yee
Jan 4, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·C NégrierT T Yee
Aug 10, 2019·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Daniel P HartMike Makris
Mar 27, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A ValentinoC Negrier
Nov 20, 2012·British Journal of Haematology·Peter W CollinsUNKNOWN UK Haemophilia Centre Doctors
Oct 1, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Christian CarulliMassimo Innocenti
Feb 5, 2013·British Journal of Haematology·Douglas W Sborov, George M Rodgers
May 21, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·M E MancusoE Santagostino
Dec 7, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·Gurhan ErturanNicholas J Goddard
Aug 8, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·P LaurouaV Guérin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.