PMID: 16534322Mar 15, 2006Paper

Activated recombinant factor VII in cardiac surgery

Current Opinion in Anaesthesiology
Marie E SteinerJerrold H Levy

Abstract

Severe bleeding after cardiac surgery is a potential problem that poses major risks and challenges. Severe bleeding after cardiac surgery still occurs despite many pharmacological approaches to decrease bleeding and reduce transfusion requirements. Activated recombinant factor VII may be a therapy that is potentially useful in the management of refractory bleeding after cardiac surgery and in other postoperative bleeding states. Several small, uncontrolled case series have suggested that activated recombinant factor VII may be useful in the management of some patients with intractable bleeding after cardiopulmonary bypass in both pediatric and adult populations. Blood loss or transfusion requirements have been reported to be substantially reduced in some patients who receive activated recombinant factor VII perioperatively. However, these reports have not established the optimal dosing or ideal timing of the administration of activated recombinant factor VII, or determined the frequency of serious adverse events related to its use. Current reports summarized in this review suggest that activated recombinant factor VII may be a promising agent in the management of uncontrolled bleeding after cardiopulmonary bypass, but additiona...Continue Reading

References

Mar 1, 1995·The Annals of Thoracic Surgery·M J Unsworth-WhiteT Treasure
May 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·M J MoultonM Rosenbloom
Jun 13, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M Al DouriR Borum Andreasen
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May 29, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Mike Herbertson

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Citations

Sep 10, 2013·Saudi Journal of Anaesthesia·Mohamed Essam Abdel-Meguid
May 10, 2011·The Journal of Thoracic and Cardiovascular Surgery·Roman M Sniecinski, Jerrold H Levy
Nov 16, 2010·Anesthesiology Clinics·Corey ScherDaniel Chien
Dec 22, 2015·Revista española de anestesiología y reanimación·J V LlauP Torrabadella
Jul 14, 2007·Heart, Lung & Circulation·Matthew P Labattaglia, Benno Ihle
Jan 16, 2009·Paediatric Anaesthesia·Nina A GuzzettaBruce E Miller
Jun 30, 2006·Journal of Thrombosis and Haemostasis : JTH·J H Levy
May 24, 2008·Transfusion·Jerrold H Levy
Jan 30, 2007·The Annals of Thoracic Surgery·Oliver WarrenThanos Athanasiou
May 31, 2014·Seminars in Cardiothoracic and Vascular Anesthesia·Robert H Thiele, Jacob Raphael
Apr 9, 2010·Current Opinion in Anaesthesiology·Jerrold H Levy, Marc Azran

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