PMID: 8957550Jan 1, 1996Paper

Activated tissue renin-angiotensin systems add to the progression of heart failure

Basic Research in Cardiology
Y M PintoK I Lie

Abstract

In this paper, we review the hypothesis that activated tissue renin-angiotensin systems play a detrimental role in heart failure. The main arguments for this idea are discussed: a) tissue renin-angiotensin systems behave functionally distinct from the circulating renin-angiotensin system; b) tissue renin-angiotensin systems are activated in heart failure; c) activated tissue renin-angiotensin systems induce cardiovascular dysfunction. Finally, this hypothesis predicts that optimal treatment in heart failure requires the inhibition of tissue renin-angiotensin systems. However, studies pertaining to this prediction are still lacking, particularly in human subjects.

References

Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M EkkerF Rougeon
Jul 1, 1986·The Journal of Clinical Investigation·D J Campbell, J F Habener
Aug 1, 1988·British Heart Journal·H M McAlpineH J Dargie
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F A MendelsohnK J Catt
Feb 1, 1993·Journal of Molecular and Cellular Cardiology·K LindpaintnerH Drexler
May 1, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Y M PintoM Paul

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