Activated TNF-α/RIPK3 signaling is involved in prolonged high fat diet-stimulated hepatic inflammation and lipid accumulation: inhibition by dietary fisetin intervention

Food & Function
Minxuan XuJun Tan

Abstract

Increasing evidence indicates that high-fat diet (HFD) is a predisposing factor for metabolic syndrome-associated systemic inflammation and nonalcoholic fatty liver disease (NAFLD). Tumor necrosis factor-α/receptor-interacting protein kinase 3 (TNF-α/RIPK3) axis has recently become regarded as an important regulator and contributor in many inflammation-related diseases. Fisetin (Fn) is a bioactive flavonoid polyphenol with anti-inflammatory and anti-tumor activity. Lately it has gained increasing attention due to its potential advantages in prevention of tumors, metabolic disorders, neuroinflammation and chronic liver injury. However, its role in NAFLD is still not fully understood. Thus, we studied whether prolonged HFD causes TNF-α/RIPK3 activation-associated hepatic steatosis, further evaluating the protective effects of Fn in HFD-fed mice. As expected, HFD promotes metabolic syndrome and pro-inflammatory cytokine generation in serum, enhances liver inflammatory infiltration-related lipid accumulation by increase of TNF-α/RIPK3 activation, ultimately resulting in development of nonalcoholic steatohepatitis. In contrast to this, dietary Fn intervention could suppress metabolic disorder and HFD-triggered hepatic function loss,...Continue Reading

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Citations

Aug 29, 2020·Journal of Medicinal Food·Myung-Sook ChoiEun-Young Kwon
Sep 27, 2020·Molecular Nutrition & Food Research·Bianca F LeonardiAline R Zimmer
Mar 17, 2021·International Immunopharmacology·Xin HuangYan Guo
May 25, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Jun-Liang PuZhong-Jun Wu
Jan 28, 2022·Cell Proliferation·Ying ZhouChunfeng Lu

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Methods Mentioned

BETA
PCR
protein assay
X-ray

Software Mentioned

ImageJ
Graph Pad
GraphPad Prism

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