Activating cardiac E2F1 induces up-regulation of pyruvate dehydrogenase kinase 4 in mice on a short term of high fat feeding

FEBS Letters
Liyan ZhangGary D Lopaschuk

Abstract

A high fat diet (HFD) induces substantial cardiac metabolic alteration(s), but the initiating molecular events remain unclear. We assessed the early cardiac energy metabolic changes in C57/BJ mice fed a HFD for 10days. Carbohydrate oxidation was markedly decreased in mice on a HFD, in which up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) was evident. Concurrently, E2F1, a transcription factor controlling PDK4 expression, was activated, as was cyclin D1, an upstream-molecule of E2F1, and eukaryotic initiation factor 4E (eIF4E), a modulator of cyclinD1 translation. Hence, HFD may initiate early cardiac metabolic alterations through the eIF4E/cyclin D1/E2F1/PDK4 axis.

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Citations

Feb 14, 2014·Nutrition & Metabolism·Shuai ZhangElizabeth R Gilbert
Jun 27, 2014·Cardiovascular Research·Osama Abo AlrobGary D Lopaschuk
Mar 22, 2016·Biochimica Et Biophysica Acta·Arata Fukushima, Gary D Lopaschuk
Oct 18, 2015·Biochimie·Timothy M GriffinLuke I Szweda
Oct 2, 2013·Journal of Molecular and Cellular Cardiology·Vikram PrasadGary E Shull
Aug 12, 2014·Biochemical Society Transactions·Osama Abo Alrob, Gary D Lopaschuk
Nov 1, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Ying HuangJie Qiao
Nov 28, 2017·Frontiers in Endocrinology·Pierre-Damien DenechaudAlbert Giralt
Jun 25, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Paul M RindlerLuke I Szweda
Jan 8, 2019·Journal of Molecular and Cellular Cardiology·Tariq R AltamimiGary D Lopaschuk

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