Abstract
A high fat diet (HFD) induces substantial cardiac metabolic alteration(s), but the initiating molecular events remain unclear. We assessed the early cardiac energy metabolic changes in C57/BJ mice fed a HFD for 10days. Carbohydrate oxidation was markedly decreased in mice on a HFD, in which up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) was evident. Concurrently, E2F1, a transcription factor controlling PDK4 expression, was activated, as was cyclin D1, an upstream-molecule of E2F1, and eukaryotic initiation factor 4E (eIF4E), a modulator of cyclinD1 translation. Hence, HFD may initiate early cardiac metabolic alterations through the eIF4E/cyclin D1/E2F1/PDK4 axis.
References
Sep 8, 1995·The Journal of Biological Chemistry·I B RosenwaldI M London
Mar 9, 1995·Nature·D O Morgan
Dec 1, 1993·Molecular and Cellular Biology·I B RosenwaldE V Schmidt
Jun 21, 1996·The Journal of Biological Chemistry·D ZhouS Chen
Apr 15, 1997·Genes & Development·J A DiehlC J Sherr
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·D TroucheT Kouzarides
Oct 29, 1998·The Journal of Biological Chemistry·R C Muise-HelmericksN Rosen
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·F Martelli, D M Livingston
Apr 20, 1999·Oncogene·A RussellD Germain
Jun 11, 1999·Genes & Development·A C GingrasN Sonenberg
Nov 24, 1999·The Journal of Biological Chemistry·C AlbaneseR G Pestell
Dec 22, 2000·Genes & Development·J R AltJ A Diehl
Jan 29, 2002·Diabetes·Boli HuangRobert A Harris
Feb 2, 2002·Nature Reviews. Molecular Cell Biology·Jeffrey M Trimarchi, Jacqueline A Lees
Jan 11, 2003·Circulation Research·Mimi Tamamori-AdachiMasa-Aki Ikeda
Apr 19, 2003·The Journal of Biological Chemistry·Dharmesh VaraGavin Brooks
Jun 25, 2003·The Biochemical Journal·Tatsuo FuruyamaNozomu Mori
May 5, 2004·The Journal of Clinical Investigation·Lluis FajasJohan Auwerx
Aug 12, 2004·The Journal of Biological Chemistry·Myint HlaingHarold S Bernstein
Nov 5, 2004·Molecular Cell·Hugh CamBrian David Dynlacht
Nov 25, 2005·Diabetes·So-Young ParkJason K Kim
Apr 21, 2006·The FEBS Journal·Makoto Araki, Kiyoto Motojima
Jun 29, 2007·Molecular Biology of the Cell·Shirin KazemiAntonis E Koromilas
Aug 19, 2007·Circulation Research·Gary D LopaschukWilliam C Stanley
Aug 1, 2008·The Journal of Biological Chemistry·Michael C F HsiehZaher Nahlé
Jan 17, 2009·Cardiovascular Research·Jordan J WrightE Dale Abel
Apr 27, 2010·BMC Neuroscience·Emilie CornilleBouchra Gharib
Aug 24, 2010·Cardiovascular Research·Liyan ZhangGary D Lopaschuk
Jun 1, 2011·PloS One·Xavier PalomerManuel Vázquez-Carrera
Nov 11, 2011·Molecular Biology of the Cell·Jaime ChuKirsten C Sadler
Citations
Oct 12, 2013·PloS One·Clair CreweLuke I Szweda
Feb 14, 2014·Nutrition & Metabolism·Shuai ZhangElizabeth R Gilbert
Jun 27, 2014·Cardiovascular Research·Osama Abo AlrobGary D Lopaschuk
Mar 22, 2016·Biochimica Et Biophysica Acta·Arata Fukushima, Gary D Lopaschuk
Oct 18, 2015·Biochimie·Timothy M GriffinLuke I Szweda
Oct 2, 2013·Journal of Molecular and Cellular Cardiology·Vikram PrasadGary E Shull
Aug 12, 2014·Biochemical Society Transactions·Osama Abo Alrob, Gary D Lopaschuk
Nov 12, 2016·The Journal of Nutritional Biochemistry·Mikael NikuMarja Mutanen
Nov 1, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Ying HuangJie Qiao
Nov 4, 2016·Oral Diseases·H ZhangC Hu
Nov 28, 2017·Frontiers in Endocrinology·Pierre-Damien DenechaudAlbert Giralt
Feb 14, 2018·The Biochemical Journal·Tariq R AltamimiGary D Lopaschuk
Jun 25, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Paul M RindlerLuke I Szweda
May 18, 2018·JCI Insight·Arata FukushimaGary D Lopaschuk
Jan 8, 2019·Journal of Molecular and Cellular Cardiology·Tariq R AltamimiGary D Lopaschuk