Activating Drugs with Sound: Mechanisms Behind Sonodynamic Therapy and the Role of Nanomedicine.

Bioconjugate Chemistry
Victor ChoiGang Zheng

Abstract

Sonodynamic therapy (SDT) is a promising therapeutic platform for minimally invasive cancer treatment in which acoustically susceptible drug agents, sonosensitizers, are activated by deep-tissue-penetrating low frequency ultrasound. Despite growing research in recent years, the field has yet to clearly elucidate broadly applicable mechanisms by which acoustic cavitation triggers sonosensitizer therapeutic activity, creating difficulties in achieving substantial and translatable therapeutic efficacy. In this review, we will critically analyze the proposed mechanisms underlying SDT and overview how nanomedicines can complement and extend these mechanisms to deliver more efficacious SDT. In doing so, we aim to highlight potential avenues toward viable implementation of SDT as a cancer therapy.

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Citations

Jan 16, 2021·Ultrasound in Medicine & Biology·Erika Toneth Ponce AyalaSebastião Pratavieira
Feb 25, 2021·Chemical Communications : Chem Comm·Wooram UmJae Hyung Park
Mar 9, 2021·Bioconjugate Chemistry·Pinunta NittayacharnAgata A Exner
Jun 25, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yifan YangZhenqing Hou
Jun 15, 2021·Chemical Science·Elizabeth J AnthonyZijin Zhang
Aug 19, 2021·Bioconjugate Chemistry·Raina M BorumJesse V Jokerst

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