Activating the Nucleic Acid-Sensing Machinery for Anticancer Immunity

International Review of Cell and Molecular Biology
Terry MedlerMichael J Gough

Abstract

Nucleic acid sensing pathways have likely evolved as part of a broad pathogen sensing strategy intended to discriminate infectious agents and initiate appropriate innate and adaptive controls. However, in the absence of infectious agents, nucleic acid sensing pathways have been shown to play positive and negative roles in regulating tumorigenesis, tumor progression and metastatic spread. Understanding the normal biology behind these pathways and how they are regulated in malignant cells and in the tumor immune environment can help us devise strategies to exploit nucleic acid sensing to manipulate anti-cancer immunity.

Citations

Jul 23, 2019·Organic & Biomolecular Chemistry·Rashi SoniAshwani Sharma
Oct 28, 2019·Oncoimmunology·Jenny SprootenAbhishek D Garg
Sep 17, 2020·Oncoimmunology·Julie Le NaourGuido Kroemer
Sep 17, 2020·Oncoimmunology·Giorgio FregaOliver Kepp
Sep 17, 2020·Oncoimmunology·Julie Le NaourErika Vacchelli
Nov 28, 2020·Cell Death & Disease·Jitka FucikovaLorenzo Galluzzi
Apr 6, 2021·Frontiers in Oncology·Terry R MedlerMichael J Gough
Apr 30, 2021·Pharmacology & Therapeutics·Pooja JainMunira Momin
Jun 3, 2021·Cells·Lorenzo Galluzzi, Abhishek D Garg
Jun 15, 2021·The EMBO Journal·Oliver KeppLorenzo Galluzzi
Feb 17, 2020·NAR Cancer·Christian BaillyBruno Quesnel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Veterinary Immunology and Immunopathology
Sudhanshu Shekhar, Xi Yang
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Liufu DengYang-Xin Fu
Frontiers in Microbiology
Lilliana Radoshevich, Olivier Dussurget
Journal of Innate Immunity
Xiaonan Dong, Beth Levine
© 2022 Meta ULC. All rights reserved