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Activating Transcription Factor 6 reduces Aβ1-42 and restores memory in Alzheimer's disease model mice

The International Journal of Neuroscience

Jan 14, 2020

Yayun DuXiaopan Wu

Abstract

OBJECTIVES: Amyloid plaques are the most important pathological hallmarks of Alzheimer's disease. The deposition of amyloid plaques will cause ER Stress. Activating Transcription Factor 6(ATF6) is a sensor of ER Stress. However, the role of ATF6 in Alzheimer's disease has not been repor...read more

Mentioned in this Paper

Promoter
Thioflavine
Spatial Memory
Protein Level - Finding
Amyloid beta-Protein Precursor
Amyloid beta-protein (1-42)
Study
Memory
ATF6 protein, human
Activating Transcription Factor 6
1
1
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Activating Transcription Factor 6 reduces Aβ1-42 and restores memory in Alzheimer's disease model mice

The International Journal of Neuroscience

Jan 14, 2020

Yayun DuXiaopan Wu

PMID: 31928492

DOI: 10.1080/00207454.2020.1715977

Abstract

OBJECTIVES: Amyloid plaques are the most important pathological hallmarks of Alzheimer's disease. The deposition of amyloid plaques will cause ER Stress. Activating Transcription Factor 6(ATF6) is a sensor of ER Stress. However, the role of ATF6 in Alzheimer's disease has not been repor...read more

Mentioned in this Paper

Promoter
Thioflavine
Spatial Memory
Protein Level - Finding
Amyloid beta-Protein Precursor
Amyloid beta-protein (1-42)
Study
Memory
ATF6 protein, human
Activating Transcription Factor 6
1
1

Similar Papers Found In These Feeds

Working Memory

Working memory is the ability to maintain and manipulate information over a period of seconds and is a core component of higher cognitive functions. Here is the latest research on working memory.

Alzheimer's Disease: Abeta

Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with accumulation of amyloid plaques, which are comprised of amyloid beta. Here is the latest research in this field.

Related Papers

Paper Details
References
  • References21
  • Citations
123
  • References21
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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