Activation and tuning of green fluorescent protein chromophore emission by alkyl substituent-mediated crystal packing

Journal of the American Chemical Society
J DongLaren M Tolbert

Abstract

O-Alkyl synthetic analogues of the green fluorescent protein chromophore are nonfluorescent in solution but demonstrate a bright emission in the crystalline state. Three-dimensional steady-state and time-resolved emission spectroscopies in the solid state, as well as single-crystal X-ray diffraction, reveal the nature of complex emission in the crystals. A hypsochromic emission shift with an increase of the alkyl size is determined by the monomer-aggregate emission ratio.

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Aug 25, 2011·Accounts of Chemical Research·Laren M TolbertKyril M Solntsev
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