PMID: 9547348May 9, 1998Paper

Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene

Molecular Pharmacology
P HonkakoskiM Negishi

Abstract

By extending previous studies of the phenobarbital (PB)-responsive 132-base pair (bp) enhancer sequence in the CYP2B10 gene, we have delimited a 51-bp enhancer element that is fully inducible by PB in mouse primary hepatocytes. Sixteen structurally unrelated phenobarbital-type inducers activated the 51-bp enhancer element in transient transfection assays. The results thus indicate that most PB-type inducers, if not all inducers, increase the transcription of the CYP2B10 gene by activating this 51-bp element, now designated PB-responsive enhancer module or PBREM.

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Citations

Mar 27, 2001·Annual Review of Pharmacology and Toxicology·T Sueyoshi, M Negishi
Jan 17, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Satoru KakizakiMasahiko Negishi
Jun 19, 2003·British Journal of Pharmacology·Michael MurrayDylan Sutton
Dec 17, 2003·Clinical Pharmacokinetics·Hongbing Wang, Edward L LeCluyse
Feb 24, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Stephanie R FaucetteEdward L LeCluyse
Dec 6, 2003·Pharmacological Reviews·Christoph Handschin, Urs A Meyer
Dec 3, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Etienne Audet-Walsh, Alan Anderson
Sep 8, 2009·Expert Opinion on Drug Metabolism & Toxicology·Etienne Audet-WalshAlan Anderson
Apr 8, 2010·Pharmaceutical Research·Subhajit Mukherjee, Sridhar Mani
Feb 12, 2014·PLoS Pathogens·Kai A KroppPeter Ghazal
Feb 26, 1999·The Journal of Biological Chemistry·T SueyoshiM Negishi
Apr 3, 2001·Journal of Biochemical and Molecular Toxicology·M YamamotoN Nemoto
Jul 29, 1999·American Journal of Respiratory Cell and Molecular Biology·T SkarinR Toftgârd
Aug 9, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Li XiaoK-C Cheng
Jun 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael PodvinecUrs A Meyer
Feb 28, 2004·Molecular Endocrinology·Karen Swales, Masahiko Negishi
Jul 12, 2008·Archives of Toxicology·Olavi PelkonenHannu Raunio
May 25, 2004·Molecular Pharmacology·Jonathan P JacksonJoyce A Goldstein
Jun 26, 2003·Annals of Medicine·Paavo HonkakoskiMasahiko Negishi
Oct 23, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Nathan J CherringtonCurtis D Klaassen
Apr 19, 2005·Archives of Pharmacal Research·Changjiang XuAh-Ng Tony Kong
Sep 16, 1999·Journal of Biochemical and Molecular Toxicology·T S KloseJ A Goldstein
Aug 5, 2003·The Journal of Biological Chemistry·Christian FrankCarsten Carlberg
Jan 16, 2008·Antimicrobial Agents and Chemotherapy·David J JohnsonStephen A Ward
Jan 18, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Masaru TsutsuiYoh-Ichi Tagawa
May 11, 2006·Drug Metabolism Reviews·Susumu Kodama, Masahiko Negishi
Sep 13, 2013·Drug Metabolism Reviews·Susumu Kodama, Masahiko Negishi
Jul 15, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xiao-Jie ZhangShu-Yun Zhang

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