Activation by inflammatory stimuli increases neutrophil binding of human immunodeficiency virus type 1 and subsequent infection of lymphocytes

Journal of Virology
Ali M GabaliLarry L Thomas

Abstract

Resting neutrophils bind human immunodeficiency virus type 1 (HIV-1) and efficiently transfer infection to lymphocytes. The present study shows that a brief activation by inflammatory stimuli increases the neutrophil binding levels of both R5 and X4 isolates of HIV-1 at least twofold. The binding occurs independently of CD4, gp120, and incubation temperature and is observed with HIV-1 propagated either in lymphocytes or in HEK293 cells. Significantly, HIV-1 bound to the activated neutrophils accelerates the infection of activated lymphocytes compared to free HIV-1 or to HIV-1 bound to resting neutrophils. It is proposed that these events may contribute to the increased risk of HIV-1 transmission at sites of mucosal infection.

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Citations

Nov 6, 2010·The Journal of Infectious Diseases·Fengwei BaiRuth R Montgomery
Dec 15, 2007·Veterinary Immunology and Immunopathology·Craig WebbSteven Dow
Apr 16, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·B S de Vries, M J Peek
Sep 4, 2016·Immunologic Research·Milena S EspíndolaFabiani G Frantz
Jan 28, 2015·The Open AIDS Journal·Vikram MehrajJean-Pierre Routy
Aug 9, 2005·Clinical and Diagnostic Laboratory Immunology·Agostino PuglieseDonato Torre
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bryan HeitPaul Kubes
Oct 6, 2017·Archives of Virology·Mahmoud Mohammad YaseenBarakat Mohammad Shabsoug
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carole ElbimJerome Estaquier
Feb 16, 2019·Respirology Case Reports·Benjamin Gerhardy
Mar 30, 2021·Frontiers in Immunology·Morris MadzimeHelen C Steel

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