Activation conditions for the induction of metabotropic glutamate receptor-dependent long-term depression in hippocampal CA1 pyramidal cells.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Wei FanUrs Gerber

Abstract

Two forms of homosynaptic long-term depression (LTD) are distinguished in hippocampal CA1 pyramidal cells, one which is NMDA receptor dependent and the other metabotropic glutamate receptor (mGluR) dependent. Although the molecular processes involved in mGluR-LTD are well characterized, the conditions of circuit activation required for its induction remain unclear. We show that mGluR-LTD cannot be induced in synaptically coupled CA3-CA1 pyramidal cell pairs. Experiments to address the underlying mechanisms indicate that, even when glutamate transporters are blocked, one presynaptic cell releases insufficient glutamate to evoke an mGluR-mediated current in a connected CA1 cell. These findings imply that extrasynaptic diffusion is not a limiting factor and are consistent with a sparse distribution of functional mGluRs in the dendritic tree of pyramidal cells. Thus, the discharge of multiple Schaffer collaterals to a targeted cell is necessary for mGluR-LTD. Our experiments indicate that approximately eight CA3 inputs to a CA1 pyramidal cell must be activated to induce mGluR-LTD.

Citations

Apr 25, 2012·Annual Review of Neuroscience·István Katona, Tamás F Freund
Mar 28, 2018·Scientific Reports·Duk-Gyu SunSunggu Yang
Jun 28, 2016·Scientific Reports·Michelangelo ColavitaFederico Massa
Dec 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yanis InglebertDominique Debanne

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