PMID: 15240712Jul 9, 2004Paper

Activation, differentiation, and migration of naive virus-specific CD8+ T cells during pulmonary influenza virus infection

The Journal of Immunology : Official Journal of the American Association of Immunologists
Christopher W Lawrence, Thomas J Braciale

Abstract

The low precursor frequency of individual virus-specific CD8(+) T cells in a naive host makes the early events of CD8(+) T cell activation, proliferation, and differentiation in response to viral infection a challenge to identify. We have therefore examined the response of naive CD8(+) T cells to pulmonary influenza virus infection with a murine adoptive transfer model using hemagglutinin-specific TCR transgenic CD8(+) T cells. Initial activation of CD8(+) T cells occurs during the first 3 days postinfection exclusively within the draining lymph nodes. Acquisition of CTL effector functions, including effector cytokine and granule-associated protease expression, occurs in the draining lymph nodes and differentially correlates with cell division. Division of activated CD8(+) T cells within the draining lymph nodes occurs in an asynchronous manner between days 3 and 4 postinfection. Despite the presence of Ag for several days within the draining lymph nodes, dividing T cells do not appear to maintain contact with residual Ag. After multiple cell divisions, CD8(+) T cells exit the draining lymph nodes and migrate to the infected lung. Activated CD8(+) T cells also disseminate throughout lymphoid tissue including the spleen and dist...Continue Reading

References

Jul 1, 1991·The Journal of General Virology·M C EichelbergerP C Doherty
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M E CosulichA Bargellesi
Sep 1, 1984·The Journal of Experimental Medicine·A E LukacherT J Braciale
Jan 1, 1995·Advances in Immunology·B A Imhof, D Dunon
Jun 1, 1994·Current Opinion in Immunology·L J Picker
May 2, 1994·Journal of Immunological Methods·A B Lyons, C R Parish
Feb 1, 1993·The Journal of Experimental Medicine·S R CardingP C Doherty
May 17, 1996·The Journal of Biological Chemistry·G PreeceA Ager
Jan 1, 1996·Annual Review of Immunology·R M ZinkernagelH Hengartner
Feb 7, 1998·The Journal of Experimental Medicine·R A WarnockU H von Andrian
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·A V Gett, P D Hodgkin
Sep 5, 1998·Immunity·J J BirdS L Reiner
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C G FengA G Bean
Jun 3, 2000·Annual Review of Immunology·J T HartyD W White
Jun 3, 2000·Annual Review of Immunology·P C Doherty, J P Christensen
Nov 28, 2000·European Journal of Immunology·A HamannD Jablonski-Westrich
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R MercadoE G Pamer
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S Z Ben-SassonW E Paul
Mar 10, 2001·Nature·R L ReinhardtM K Jenkins
Mar 13, 2001·Annual Review of Immunology·M K JenkinsK A Pape
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·D R MarshallP C Doherty
Jun 29, 2002·Current Opinion in Immunology·Leo Lefrançois, David Masopust
Aug 2, 2002·Immunity·Huub T C KreuwelLinda A Sherman
Aug 7, 2002·The Journal of Experimental Medicine·Javier HernándezLinda A Sherman
Oct 9, 2002·The Journal of Experimental Medicine·Eulogia RománSusan L Swain
Nov 5, 2002·Annual Review of Immunology·Phillip Wong, Eric G Pamer
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathalie Auphan-AnezinAnne-Marie Schmitt-Verhulst
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony M ByersAron E Lukacher
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel L BarberRafi Ahmed
Jul 31, 2003·Nature Immunology·Andrea A Itano, Marc K Jenkins

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Citations

Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher W LawrenceThomas J Braciale
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donald R DrakeThomas J Braciale
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Noelle K PolakosDavid J Topham
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heesik YoonThomas J Braciale
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marian A FernandezCheryl A Jones
Jul 2, 2008·The Journal of Experimental Medicine·Jodi McGillKevin L Legge
Aug 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·William W ReileyDavid L Woodland
Oct 11, 2008·Expert Review of Vaccines·Peter Charles Leonard Beverley, Elma Zaven Tchilian
Jul 29, 2009·Infection and Immunity·Bisweswar NandiGary M Winslow
Jan 7, 2010·BMC Cancer·Sitti Rahma Abdul HafidKalanithi Nesaretnam
May 19, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Shelby H SteinmeyerKim M Pepin
Sep 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jodi McGill, Kevin L Legge
Dec 29, 2010·The Journal of Experimental Medicine·Matthew M HuffordThomas J Braciale
Sep 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hulin WuDavid J Topham
Apr 1, 2011·Mucosal Immunology·K B UrdahlJ D Ernst
Aug 8, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Moyar Qing GeDavid Michael Kemeny
Jun 23, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia E PrierStephen J Turner
Aug 6, 2019·Frontiers in Immunology·Cynthia Calzas, Christophe Chevalier
Mar 11, 2020·Mucosal Immunology·Shuangshuang YangBaohua Zhou
Aug 30, 2020·International Journal of Molecular Sciences·Freya R Shepherd, James E McLaren
Sep 26, 2020·Frontiers in Cellular and Infection Microbiology·Kayla Frank, Silke Paust
Feb 24, 2006·Emerging Infectious Diseases·Paul G ThomasPeter C Doherty
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason K WhitmireJ Lindsay Whitton
Jul 11, 2006·Immunological Reviews·Hirokazu HikonoDavid L Woodland
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Misty R JenkinsStephen J Turner
Mar 18, 2005·Annual Review of Immunology·Jonathan W Yewdell, S M Mansour Haeryfar
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark J DobrzanskiKathleen A Rewers-Felkins
Oct 29, 2008·Annual Review of Immunology·Jacob E Kohlmeier, David L Woodland
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Misty R JenkinsStephen J Turner
Feb 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rebecca M ReamThomas J Braciale
May 19, 2010·Expert Review of Respiratory Medicine·Nicole La GrutaStephen J Turner
Jun 6, 2009·Current Protocols in Cell Biology·Emilio FlañoJoan E Durbin
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erik L BrincksKevin L Legge
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stacey L Sheasley-O'NeillVictor H Engelhard
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ching-Hung ShenJianzhu Chen
Aug 1, 2009·Journal of Leukocyte Biology·Jodi McGillKevin L Legge
Nov 29, 2008·European Journal of Immunology·Shaza A FadelAndrew D Luster
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rahul KushwahJim Hu

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