Activation Effects of Carnosine- and Histidine-Containing Dipeptides on Human Carbonic Anhydrases: A Comprehensive Study

International Journal of Molecular Sciences
Giulio VistoliClaudiu T Supuran

Abstract

l-Carnosine (β-Ala-l-His) and several other histidine-containing peptides, including two N-methylated forms on the imidazole ring (l-anserine and l-balenine), two derivatives modified on the carboxyl function (carcinine and l-carnosinamide), two analogues differing in the length of the N-terminal residue (l-homocarnosine and Gly-l-His) and the N-acetyl derivatives, were investigated as activators of four isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). The four human isoforms hCA I, II, VA and IX were activated in the low to high micromolar range, with a rather complex structure activity relationship. A performed computational study allowed us to rationalize these results and to propose a binding mode of these activators within the enzyme active site. Similarly to other CA activators, the here studied peptides could find relevant pharmacological applications such as in the management of CA deficiencies, for therapy memory and enhancing cognition or for artificial tissues engineering.

References

Aug 30, 2005·Progress in Biophysics and Molecular Biology·Richard D Vaughan-JonesPawel Swietach
Sep 12, 2007·Bioinformatics·M A LarkinD G Higgins
Jan 3, 2008·Nature Reviews. Drug Discovery·Claudiu T Supuran
Jan 8, 2009·Journal of Chemical Information and Modeling·Oliver KorbThomas E Exner
Jul 15, 2009·Advances in Food and Nutrition Research·Alan R Hipkiss
Jun 4, 2010·Journal of Cellular and Molecular Medicine·Giancarlo AldiniMarina Carini
Oct 19, 2013·Physiological Reviews·Alexander A BoldyrevWim Derave
Feb 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francesco BelliaEnrico Rizzarelli
Oct 2, 2015·Aging and Disease·José H CararoGustavo da C Ferreira
Dec 20, 2015·Journal of Alzheimer's Disease : JAD·Tatsuhiro HisatsuneHiroshi Matsuda
Feb 24, 2016·Oxidative Medicine and Cellular Longevity·V D ProkopievaS A Ivanova
Jun 28, 2016·Maturitas·Alan R HipkissBarbora de Courten
Jul 14, 2016·The Biochemical Journal·Claudiu T Supuran
Jul 19, 2016·International Journal of Biological Macromolecules·Muthuraman PanduranganDoo Hwan Kim
Jul 20, 2016·ACS Chemical Neuroscience·Xiaoyu HuXingyu Chen
Feb 17, 2018·ChemMedChem·Andrea N Bootsma, Steven E Wheeler
Feb 27, 2018·Future Medicinal Chemistry·Claudiu T Supuran
Feb 28, 2018·Current Protein & Peptide Science·Sebastian KwiatkowskiJakub Drozak
Jun 23, 2018·Current Medicinal Chemistry·Murat BozdagFabrizio Carta
Sep 19, 2018·The Journal of Clinical Investigation·Ethan J AndersonGiancarlo Aldini
Nov 19, 2018·Amino Acids·Jingjing ZhaoShahid P Baba
Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Marouan RamiSaïd Yous
Apr 29, 2019·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Eimear DolanBruno Gualano
May 15, 2019·Medicine and Science in Sports and Exercise·Joseph J MatthewsCraig Sale
Jul 20, 2019·Nutrients·Nobutaka MasuokaTatsuhiro Hisatsune
Aug 9, 2019·International Journal of Molecular Sciences·Rossana Occhipinti, Walter F Boron

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Citations

Apr 28, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Niccolò ChiaramonteMaria Novella Romanelli
Aug 12, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Claudiu T Supuran
Oct 27, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Alessio NocentiniClaudiu T Supuran
May 4, 2021·Digestive Diseases and Sciences·Minna NortunenTuomo J Karttunen

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