PMID: 1206741Nov 1, 1975Paper

Activation in vitro of mouse macrophages by syngeneic, allogeneic, or xenogeneic lymphocyte supernatants

Journal of the National Cancer Institute
I J Fidler

Abstract

Macrophages from normal C57BL/6 mice, those with a subcutaneous B16 melanoma, and mice immunized against the tumor were examined for in vitro cytotoxicity to B16 tumor cells. Macrophages were treated by incubation with supernatants from B16 cells grown either in unmixed cultures or in cultures containing syngeneic, normal, or sensitized allogeneic (A mouse), or xenogeneic (rat) lymphocytes. The various treated and untreated macrophages were then cultured for 5 days with viable B16 cells prelabeled with 125I-5-iodo-2'-deoxyuridine; the cultures were terminated, and the extent of destruction of the B16 target cells was determined from the amounts of radioactivity remaining in adherent tumor cells. Of the untreated macrophages, only those from immunized mice were cytotoxic to the tumor cells; macrophages from normal and tumor-bearing mice became cytotoxic by incubation with supernatants from cultures containing lymphocytes from immunized syngeneic mice, sensitized allogeneic mice, or sensitized rats; and macrophages incubated with supernatants from cultures containing normal nonsensitized allogeneic or xenogeneic lymphocytes showed no cytotoxicity. Thes results suggested that macrophages from tumor-bearing animals are potentially ...Continue Reading

Citations

Sep 1, 1987·The Journal of Pharmacy and Pharmacology·Y Tabata, Y Ikada
Jan 1, 1985·Journal of Cancer Research and Clinical Oncology·M KanekoH Iwasaki
Mar 1, 1983·Journal of Clinical Pathology·R J Sokol, G Hudson
Jul 1, 1979·The British Journal of Surgery·R WindleP R Bell
Aug 1, 1988·Journal of Surgical Oncology·K YasumotoK Nomoto
Jan 1, 1977·Immunological Communications·M Horowitz, B F Argyris
Aug 1, 1982·Cancer·D J Cameron, P O'Brien
Nov 15, 1984·International Journal of Cancer. Journal International Du Cancer·K R Patel, J D Baldeschwieler
Jun 15, 1980·International Journal of Cancer. Journal International Du Cancer·A MantovaniR B Herberman
Sep 15, 1984·International Journal of Cancer. Journal International Du Cancer·K R Patel, J D Baldeschwieler
Aug 31, 1981·Biochimica Et Biophysica Acta·I R Hart, I J Fidler
Apr 1, 1982·Infection and Immunity·C Y Lu, E R Unanue
Mar 1, 1986·Human Pathology·M C Cohen, S Cohen
Jul 15, 1977·Science·J B HibbsJ B Weinberg

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