Jun 1, 1976

Activation-induced restoration of sensorimotor functions in rats with dopamine-depleting brain lesions

Journal of Comparative and Physiological Psychology
J F MarshallE M Stricker


Bilateral electrolytic lesions of the lateral hypothalamus or intraventricular 6-hydroxydopamine injections produced substantial depletions of striatal dopamine in rates. All animals with brain damage showed marked sensorimotor impairments. However, they began to move and respond appropriately to environmental stimuli when placed in a sink of water, in a shallow ice bath, or among a colony of cats or rats. A reversal of the sensorimotor dysfunctions was still apparent shortly after the animals were removed from each activating situation. However, the terapeutic effects dissipated rapidly, and by 4 hr after an exposure the rats responded as poorly as they had prior to activation. These findings are strikingly similar to the "paradoxical kinesia" seen in parkinsonism, a clinical disorder attributed to degeneration of central dopamine-containing neurons. Collectively, they suggest the importance of activation in maintaining responsiveness to senory stimuli in rats following dopamine-depleting brain lesions.

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Mentioned in this Paper

Vigilance, Cortical
Behavior, Animal
Organum Vasculosum Laminae Terminalis
Brain Chemistry
Brain Damage, Chronic
White Coat Hypertension

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